For immunochemical detection of GSK3β (phospho-Ser9)
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GSK3β (Phospho-Ser9) Rabbit Monoclonal Antibody (Clone RM453)

Item No. 42815

Product Insert (PDF)
Technical Information
Synonyms
  • Glycogen Synthase Kinase 3β
  • GSK3B
  • Serine/threonine-protein Kinase GSK3B
Immunogen
A peptide corresponding to GSK3β (phospho-Ser9)
Clone Designation
RM453
Formulation (Request formulation change)
100 µl of protein A-affinity purified monoclonal antibody
Storage Buffer
PBS, with 50% glycerol, 1% BSA, and 0.09% sodium azide
Host
Rabbit
Isotype
IgG
Applications
IHC, WB
Cross Reactivity
(+) GSK3β (phospho-Ser9)(-) Non-phosphorylated GSK3β
Species Reactivity
(+) Human(+) Mouse(+) Rat
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

    100 µl

    $411

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    Cayman Chemical
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    Product Description

    Glycogen synthase kinase 3β (GSK3β) is a serine/threonine protein kinase that has roles in numerous signaling pathways and cellular processes, including cell proliferation and survival, as well as neural development and plasticity.1,2 It is composed of an N-terminal β-strand domain, a kinase domain, and a C-terminal α-helical domain.3 GSK3β is constitutively active, ubiquitously expressed, and localizes predominantly to the cytosol but is also found in the nucleus and mitochondria.2,4 It is inhibited by phosphorylation at serine 9 (Ser9), which is mediated by a variety of kinases, including PKA and Akt, and has roles in insulin, growth factor, and Wnt signaling pathways.2 GSK3β is involved in several pathophysiological conditions, such as diabetes, cancer, inflammation, and neurological or psychiatric disorders, including Alzheimer's disease, Parkinson's disease, and bipolar disorder.4,1 Cayman's GSK3β (Phospho-Ser9) Rabbit Monoclonal Antibody (Clone RM453) can be used for immunohistochemistry (IHC) and Western blot (WB) applications.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Yang, K., Chen, Z., Gao, J., et al. The key roles of GSK-3β in regulating mitochondrial activity. Cell. Physiol. Biochem. 44(4), 1445-1459 (2017).

    2. Krishnankutty, A., Kimura, T., Saito, T., et al. In vivo regulation of glycogen synthase kinase 3β activity in neurons and brains. Sci. Rep. 7(1), 8602 (2017).

    3. ter Haar, E., Coll, J.T., Austen, D.A., et al. Structure of GSK3β reveals a primed phosphorylation mechanism. Nat. Struct. Biol. 8(7), 593-596 (2001).

    4. Beurel, E., Grieco, S.F., and Jope, R.S. Glycogen synthase kinase-3 (GSK3): Regulation, actions, and diseases. Pharmacol. Ther. 148, 114-131 (2015).