A peptide antagonist of the NK2B receptor
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R 396 (trifluoroacetate salt)

Item No. 43083

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-acetyl-L-leucyl-L-α-aspartyl-L-glutaminyl-L-tryptophyl-L-phenylalanyl-glycinamide, trifluoroacetate salt
Synonyms
  • Ac-Leu-Asp-Gln-Trp-Phe-Gly-NH2
Molecular Formula
C39H51N9O10 • XCF3COOH
Formula Weight
805.9
Purity
≥90%
Formulation (Request formulation change)
A solid
Peptide Sequence
Ac-LDQWFG-NH2
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥ 10 mg/ml
SMILES
NC(CNC([C@H](CC1=CC=CC=C1)NC([C@@H](NC([C@H](CCC(N)=O)NC([C@H](CC(O)=O)NC([C@@H](NC(C)=O)CC(C)C)=O)=O)=O)CC2=CNC3=CC=CC=C23)=O)=O)=O.O=C(O)C(F)(F)F
InChi Code
InChI=1S/C39H51N9O10.C2HF3O2/c1-21(2)15-28(44-22(3)49)37(56)48-31(18-34(52)53)39(58)45-27(13-14-32(40)50)36(55)47-30(17-24-19-42-26-12-8-7-11-25(24)26)38(57)46-29(35(54)43-20-33(41)51)16-23-9-5-4-6-10-23;3-2(4,5)1(6)7/h4-12,19,21,27-31,42H,13-18,20H2,1-3H3,(H2,40,50)(H2,41,51)(H,43,54)(H,44,49)(H,45,58)(H,46,57)(H,47,55)(H,48,56)(H,52,53);(H,6,7)/t27-,28-,29-,30-,31-;/m0./s1
InChi Key
LVKWDYYZVUJQEI-FIYBGCGXSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    5 mg

    $50

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    10 mg

    $95

    Add

    25 mg

    $224

    Add

    50 mg

    $396

    Add
    Product Description

    R 396 is a peptide antagonist of the neurokinin-2B (NK2B) receptor (pA2 = 7.63).1 It is selective for the NK2B receptor over NK1, NK2A, and NK3 receptors (pA2s = <5, 5.41, and <5, respectively). Intracerebroventricular administration of R 396 (650 pmol/animal) inhibits increases in mean arterial blood pressure, heart rate, face washing, and grooming induced by neurokinin A (NKA) but not substance P (Item No. 24035) in conscious rats.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Rovero, P., Astolfi, M., Manzini, S., et al. Structure-activity relationship study of R396, an NK2 tachykinin antagonist selective for the NK2B receptor subtype. Neuropeptides 23(3), 143-145 (1992).

    2. Tschöpe, C., Picard, P., Culman, J., et al. Use of selective antagonists to dissociate the central cardiovascular and behavioural effects of tachykinins on NK1 and NK2 receptors in the rat. Br. J. Pharmacol. 107(3), 750-755 (1992).