A BSA complex with palmitic acid
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BSA-Palmitate Saturated Fatty Acid Complex (1.67 mM)

Item No. 43443

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • Bovine Serum Albumin-PA
  • Bovine Serum Albumin-Palmitate
  • BSA-Hexadecanoic Acid
  • BSA-PA
Source
Bovine
Formulation (Request formulation change)
1.67 mM Palmitate:0.8 mM BSA (2:1 palmitate:BSA) in 150 mM sodium chloride, pH 7.4
Origin
Animal/Bovine
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    5 ml

    $182

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    Product Description

    BSA-Palmitate Saturated Fatty Acid Complex (1.67 mM) is composed of palmitic acid (Item Nos. 10006627 | 43561) and fatty acid-free bovine serum albumin (BSA) at an approximately 2:1 molar ratio of palmitate:BSA. It can be used for efficient fatty acid delivery to cells in culture for the purpose of monitoring fatty acid oxidation, lipid metabolism, and inflammatory signaling pathways, including in studies of obesity-related inflammation and insulin resistance.1,2,3 It can also be used to study the effect of long-chain fatty acid uptake on gene and protein expression, lipid droplet formation, hepatocyte lipid accumulation, and oxidative stress.4,5,6 Cayman’s BSA-Palmitate Saturated Fatty Acid Complex (1.67 mM) is suitable for use in short-term cell culture applications (acute treatment to 18 hours); however, for long-term applications (25+ hours) the product should be filter-sterilized using a 0.2 µm filter and sterile receptacle, which will not affect its performance. When used at the same lipid concentration as BSA-Palmitate Saturated Fatty Acid Complex (5 mM) (Item No. 29558) or BSA-Palmitate Saturated Fatty Acid Complex (10 mM) (Item No. 44156), which have a 6:1 molar ratio of palmitate:BSA, this product provides a lower free palmitate concentration, which may reduce the likelihood of acute lipotoxicity.7 For best results, it is recommended that this product be used in conjunction with Cayman’s BSA Control for BSA-Fatty Acid Complexes (5 mM) (Item No. 29556), prepared with fatty acid-free BSA.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Alsabeeh, N., Chausse, B., Kakimoto, P.A., et al. Cell culture models of fatty acid overload: Problems and solutions. Biochim. Biophys. Acta Mol. Cell Biol. Lipids 1863(2), 143-151 (2018).

    2. Wang, D., Green, M.F., McDonnell, E., et al. Oxygen flux analysis to understand the biological function of sirtuins. Methods Mol. Biol. 1077, 241-258 (2013).

    3. Radin, M.S., Sinha, S., Bhatt, B.A., et al. Inhibition or deletion of the lipopolysaccharide receptor Toll-like receptor-4 confers partial protection against lipid-induced insulin resistance in rodent skeletal muscle. Diabetologia 51(2), 336-346 (2008).

    4. Muthusamy, G., Liu, C.-C., and Johnston, A.N. Deletion of PGAM5 downregulates FABP1 and attenuates long-chain fatty acid uptake in hepatocellular carcinoma. Cancers (Basel) 15(19), 4796 (2023).

    5. Das, S., Finney, A.C., Anand, S.K., et al. Inhibition of hepatic oxalate overproduction ameliorates metabolic dysfunction-associated steatohepatitis. Nat. Metab. 6(10), 1939-1962 (2024).

    6. Guilfoyle-Speese, A., Patel, K., Ghanwat, A.H., et al. Short-chain fatty acids and palmitate induce distinct metabolic and phenotypic signatures in normal and ischemic skeletal muscle microvascular endothelial cells. Cells 15(6), 493 (2026).

    7. Richieri, G.V., Anel, A., and Kleinfeld, A.M. Interactions of long-chain fatty acids and albumin: Determination of free fatty acid levels using the fluorescent probe ADIFAB. Biochemistry 32(29), 7574-7580 (1993).