An internal standard for the quantification of DL-homocystine
Related Products
Unlabeled Version(s)
36223DL-Homocystine
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DL-Homocystine-d8

Item No. 43799

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4,4′-dithiobis[2-amino-butanoic-3,3,4,4-d4 acid]
CAS Number
108641-82-3
Molecular Formula
C8H8D8N2O4S2
Formula Weight
276.4
Purity
≥99% deuterated forms (d1-d8)
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: Slightly Soluble: 0.1-1 mg/mlHydrochloric Acid: Slightly Soluble: 0.1-1 mg/mlWater: Slightly Soluble: 0.1-1 mg/ml
SMILES
OC(C(N)C([2H])([2H])C([2H])([2H])SSC([2H])([2H])C([2H])([2H])C(N)C(O)=O)=O
InChi Code
InChI=1S/C8H16N2O4S2/c9-5(7(11)12)1-3-15-16-4-2-6(10)8(13)14/h5-6H,1-4,9-10H2,(H,11,12)(H,13,14)/i1D2,2D2,3D2,4D2
InChi Key
ZTVZLYBCZNMWCF-SVYQBANQSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

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    10 mg

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    25 mg

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    50 mg

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    Product Description

    DL-Homocystine-d8 is intended for use as an internal standard for the quantification of DL-homocystine (Item No. 36223) by GC- or LC-MS. DL-Homocystine is an oxidized dimeric form of homocysteine (Item No. 30285). It inhibits CDNB-induced L-cystine (Item No. 31727) transport into isolated human erythrocytes by 75% when used at a concentration of 2.5 mM.1 DL-Homocystine increases the number of circulating endothelial cells and permeability of the pulmonary microcirculation and decreases the number of circulating platelets, as well as activates venostatic thrombosis induced by bowel loop ligation in a rat model of homocystinemia, an inborn error of metabolism characterized by a deficiency in cystathionine β-synthase (CBS) that is associated with thrombosis and atherosclerosis.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ohtsuka, Y., Kondo, T., and Kawakami, Y. Oxidative stresses induced the cystine transport activity in human erythrocytes. Biochem. Biophys. Res. Commun. 155(1), 160-166 (1988).

    2. Hladovec, J. Experimental homocystinemia, endothelial lesions and thrombosis. Blood Vessels 16(4), 202-205 (1979).