A metabolism modifying agent
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Labeled Version(s)
439482-Hydroxyisobutyric Acid-d6
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2-Hydroxyisobutyric Acid

Item No. 43901

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-hydroxy-2-methyl-propanoic acid
CAS Number
594-61-6
Synonyms
  • Acetonic Acid
  • 2-HIBA
  • 2-Methyllactic Acid
  • NSC 4505
  • NSC 402158
Molecular Formula
C4H8O3
Formula Weight
104.1
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥10 mg/mlEthanol: Soluble: ≥10 mg/mlPBS pH 7.2: Soluble: ≥10 mg/ml
SMILES
O=C(C(C)(C)O)O
InChi Code
InChI=1S/C4H8O3/c1-4(2,7)3(5)6/h7H,1-2H3,(H,5,6)
InChi Key
BWLBGMIXKSTLSX-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    50 g

    $36

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    100 g

    $68

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    Cayman Chemical
    Explore Obesity & Metabolic Disease Resources

    Discover high-quality research tools to investigate GLP-1 mechanisms and next-generation metabolic targets.

    OBESITY RESEARCH SOLUTIONS
    Product Description

    Hydroxyisobutyric acid is a metabolism modifying agent.1,2 It inhibits glutathione-induced decreases in NAD/NADH ratios, ATP levels, and maximal and basal oxygen consumption rates in PC12 adrenal medulla cells.1 2-Hydroxyisobutyric acid (10 mM) increases lipid droplet size, decreases reactive oxygen species (ROS), and increases lifespan in C. elegans.2 It reduces blood glucose levels, decreases the latency to escape in the Barnes maze test, and increases brain Bdnf, nerve growth factor (Ngf), and glutathione (GSH) levels in a db/db mouse model of diabetic neuropathy when administered at doses of 15 or 30 mg/kg per day.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Xie, M., Gu, S., Liu, Y., et al. 2-Hydroxyisobutyric acid targeted binding to MT-ND3 boosts mitochondrial respiratory chain homeostasis in hippocampus to rescue diabetic cognitive impairment. Redox Biol. 79, 103446 (2025).

    2. Schifano, E., Conta, G., Preziosi, A., et al. 2-hydroxyisobutyric acid (2-HIBA) modulates ageing and fat deposition in Caenorhabditis elegans. Front. Mol. Biosci. 9, 986022 (2022).