An internal standard for the quantification of 2-hydroxyisobutyric acid
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Unlabeled Version(s)
439012-Hydroxyisobutyric Acid
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2-Hydroxyisobutyric Acid-d6

Item No. 43948

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-hydroxy-2-(methyl-d3)-propanoic-3,3,3-d3 acid
CAS Number
40662-45-1
Synonyms
  • Acetonic acid-d6
  • 2-HIBA-d6
  • 2-Methyllactic acid-d6
Molecular Formula
C4H2D6O3
Formula Weight
110.1
Purity
≥99% deuterated forms (d1-d6)
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥10 m/mlEthanol: Sparingly soluble: 1-10 mg/mlPBS pH 7.2: Sparingly soluble: 1-10 mg/ml
SMILES
OC(C([2H])([2H])[2H])(C(O)=O)C([2H])([2H])[2H]
InChi Code
InChI=1S/C4H8O3/c1-4(2,7)3(5)6/h7H,1-2H3,(H,5,6)/i1D3,2D3
InChi Key
BWLBGMIXKSTLSX-WFGJKAKNSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    Cayman Chemical
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    OBESITY RESEARCH SOLUTIONS
    Product Description

    2-Hydroxyisobutyric acid-d6 is intended for use as an internal standard for the quantification of 2-hydroxyisobutyric acid by GC- or LC-MS. 2-Hydroxyisobutyric acid is a metabolism modifying agent.1,2 It inhibits glutathione-induced decreases in NAD/NADH ratios, ATP levels, and maximal and basal oxygen consumption rates in PC12 adrenal medulla cells.1 2-Hydroxyisobutyric acid (10 mM) increases lipid droplet size, decreases reactive oxygen species (ROS), and increases lifespan in C. elegans.2 It reduces blood glucose levels, decreases the latency to escape in the Barnes maze test, and increases brain Bdnf, nerve growth factor (Ngf), and glutathione (GSH) levels in a db/db mouse model of diabetic neuropathy when administered at doses of 15 or 30 mg/kg per day.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Xie, M., Gu, S., Liu, Y., et al. 2-Hydroxyisobutyric acid targeted binding to MT-ND3 boosts mitochondrial respiratory chain homeostasis in hippocampus to rescue diabetic cognitive impairment. Redox Biol. 79, 103446 (2025).

    2. Schifano, E., Conta, G., Preziosi, A., et al. 2-hydroxyisobutyric acid (2-HIBA) modulates ageing and fat deposition in Caenorhabditis elegans. Front. Mol. Biosci. 9, 986022 (2022).