An internal standard for the quantification of indole-3-propionic acid
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Unlabeled Version(s)
28821Indole-3-propionic Acid
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Indole-3-propionic Acid-d2

Item No. 43990

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1H-indole-3-d2-propanoic acid
CAS Number
2469257-98-3
Synonyms
  • 3-Indolepropionic Acid-d2
Molecular Formula
C11H9D2NO2
Formula Weight
191.2
Purity
≥99% deuterated forms (d1-d2)
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble
SMILES
OC(C([2H])([2H])CC1=CNC2=CC=CC=C12)=O
InChi Code
InChI=1S/C11H11NO2/c13-11(14)6-5-8-7-12-10-4-2-1-3-9(8)10/h1-4,7,12H,5-6H2,(H,13,14)/i6D2
InChi Key
GOLXRNDWAUTYKT-NCYHJHSESA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $39

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    5 mg

    $164

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    10 mg

    $270

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    Product Description

    Indole-3-propionic Acid-d2 is intended for use as an internal standard for the quantification of indole-3-propionic acid (Item No. 28821) by GC- or LC-MS. Indole-3-propionic acid is a bacterial metabolite that has antioxidant and neuroprotective activities.1,2,3 It scavenges ABTS (Item No. 27317) radicals in a cell-free assay when used at concentrations ranging from 50 to 150 µM and decreases hydrogen peroxide-induced malondialdehyde (MDA) levels in rat striatal membranes (IC50 = 180 µM).2 Indole-3-propionic acid also reduces increases in MDA levels induced by amyloid β (1-42) (Item No. 20574) in PC12 cells.4 It decreases ischemia-induced increases in cell death of pyramidal neurons and levels of 4-hydroxy nonenal (HNE; Item No. 32100) and glial fibrillary acidic protein (GFAP) in the hippocampal CA1 region in gerbils when administered at a dose of 10 mg/kg per day.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Wikoff, W.R., Anfora, A.T., Liu, J., et al. Metabolomics analysis reveals large effects of gut microflora on mammalian blood metabolites. Proc. Natl. Acad. Sci. USA 106(10), 3698-3703 (2009).

    2. Poeggeler, B., Pappolla, M.A., Hardeland, R., et al. Indole-3-propionate: A potent hydroxyl radical scavenger in rat brain. Brain Res. 815(2), 382-388 (1999).

    3. Hwang, I.K., Yoo, K.-Y., Li, H., et al. Indole-3-propionic acid attenuates neuronal damage and oxidative stress in the ischemic hippocampus. J. Neurosci. Res. 87(9), 2126-2137 (2009).

    4. Chyan, Y.-J., Poeggeler, B., Omar, R.A., et al. Potent neuroprotective properties against the Alzheimer β-amyloid by an endogenous melatonin-related indole structure, indole-3-propionic acid. The Journal of Biological Chemisty 274(31), 21937-21942 (1999).