Gly-Arg-Gly-Asp-Ser-Pro (trifluoroacetate salt)
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Gly-Arg-Gly-Asp-Ser-Pro (trifluoroacetate salt)

Item No. 44476

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
glycyl-L-arginylglycyl-L-α-aspartyl-L-seryl-L-proline, trifluoroacetate salt
Molecular Formula
C22H37N9O10 • XCF3COOH
Formula Weight
587.6
Purity
≥98%
Formulation (Request formulation change)
A solid
Peptide Sequence
GRGDSP-OH
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly soluble: 1-10 mg/mlPBS (pH 7.2): Soluble: ≥ 10 mg/ml
SMILES
N=C(N)NCCC[C@H](NC(CN)=O)C(NCC(N[C@@H](CC(O)=O)C(N[C@@H](CO)C(N1[C@@H](CCC1)C(O)=O)=O)=O)=O)=O.O=C(O)C(F)(F)F
InChi Code
InChI=1S/C22H37N9O10.C2HF3O2/c23-8-15(33)28-11(3-1-5-26-22(24)25)18(37)27-9-16(34)29-12(7-17(35)36)19(38)30-13(10-32)20(39)31-6-2-4-14(31)21(40)41;3-2(4,5)1(6)7/h11-14,32H,1-10,23H2,(H,27,37)(H,28,33)(H,29,34)(H,30,38)(H,35,36)(H,40,41)(H4,24,25,26);(H,6,7)/t11-,12-,13-,14-;/m0./s1
InChi Key
SVJVLOLHIALTGU-ZMNOQRQPSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

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    1 mg

    $25

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    5 mg

    $106

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    10 mg

    $200

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    50 mg

    $750

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    Product Description

    Gly-Arg-Gly-Asp-Ser-Pro (GRGDSP) is an RGD-containing integrin-blocking peptide.1 It inhibits integrin α5β1 and integrin αVβ3 (IC50s = 200 and 20 nM, respectively). GRGDSP (1 nM) induces chemotaxis of primary human foreskin fibroblasts (HFFs).2 It reduces angiogenesis induced by basic FGF (bFGF) in a chick chorioallantoic membrane (CAM) assay when used at a concentration of 10 µg/egg.3 GRGDSP (10 µg/animal) decreases tumor volume and increases survival in a collagen-induced paclitaxel-resistant MCF-7 breast cancer mouse xenograft model.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Koivunen, E., Gay, D.A., and Ruoslahti, E. Selection of peptides binding to the ɑ5 β1 integrin from phage display library. The Journal of Biological Chemisty 68(27), 20205-20210 (1993).

    2. Knapp, D.M., Helou, E.F., and Tranuillo, R.T. A fibrin or collagen gel assay for tissue cell chemotaxis: assessment of fibroblast chemotaxis to GRGDSP. Exp. Cell Res. 47(2), 543-553 (1999).

    3. Kim, E.Y., Bang, J.Y., Chang, S.I., et al. A novel integrin α5β1 antagonistic peptide, A5-1, screened by Protein Chip system as a potent angiogenesis inhibitor. Biochem. Biophys. Res. Commun. 377(4), 1288-1293 (2008).

    4. Li, X., Li, Q., Yu, X., et al. Reverse of microtubule-directed chemotherapeutic drugs resistance induced by cancer-associated fibroblasts in breast cancer. Onco. Targets Ther. 12, 7963-7973 (2019).