A furanoflavonoid with diverse biological activities
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Karanjin

Item No. 44518

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-methoxy-2-phenyl-4H-furo[2,3-h]-1-benzopyran-4-one
CAS Number
521-88-0
Synonyms
  • NSC 335755
Molecular Formula
C18H12O4
Formula Weight
292.3
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Chloroform: Slightly soluble: 0.1-1 mg/ml
SMILES
O=C1C(OC)=C(C2=CC=CC=C2)OC3=C4C=COC4=CC=C13
InChi Code
InChI=1S/C18H12O4/c1-20-18-15(19)13-7-8-14-12(9-10-21-14)17(13)22-16(18)11-5-3-2-4-6-11/h2-10H,1H3
InChi Key
LKPQNZRGGNOPPU-UHFFFAOYSA-N
Origin
Plant/Pongamia pinnata (L.) Pierre
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    5 mg

    $64

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    10 mg

    $122

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    25 mg

    $288

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    50 mg

    $512

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    Product Description

    Karanjin is a furanoflavonoid that has been found in P. pinnata and has diverse biological activities.1,2,3,4,5 It scavenges DPPH (Item No. 14805) and ABTS (Item No. 27317) radicals (IC50s = 8,440 and 639.72 µg/ml, respectively) and reduces ferric to ferrous iron in a ferric reducing antioxidant power (FRAP) assay (IC50 = 0.46 mM).1 Karanjin inhibits lipoxygenase (LO) and protein tyrosine phosphatase 1B (PTP1B) in cell-free assays (IC50s = 120.6 and 84.5 µM, respectively) and volume-regulated anion channel (VRAC) currents in HEK293 cells (IC50 = 10 µM).1,2,3 It is selectively cytotoxic to MDA-MB-231, HeLa, NCI H460, and HepG2 cancer cells over mouse embryonic fibroblasts (MEFs; IC50s = 50.42, 47.05, 48.04, 62.95, and 624.26 µg/ml, respectively).4 Karanjin (50 mg/kg) reduces xylene-induced ear edema in rats and ovariectomy-induced bone loss in mice.1,5 It also decreases blood glucose levels in diabetic db/db mice.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Rekha, M.J., Bettadaiah, B.K., Muthukumar, S.P., et al. Synthesis, characterization and anti-inflammatory properties of karanjin (Pongamia pinnata seed) and its derivatives. Bioorg. Chem. 106, 104471 (2021).

    2. Tamrakar, A.K., Yadav, P.P., Tiwari, P., et al. Identification of pongamol and karanjin as lead compounds with antihyperglycemic activity from Pongamia pinnata fruits. J. Ethnopharmacol. 118(3), 435-439 (2008).

    3. Xue, Y., Li, H., Zhang, Y., et al. Natural and synthetic flavonoids, novel blockers of the volume-regulated anion channels, inhibit endothelial cell proliferation. Pflugers Arch. 470(10), 1473-1483 (2018).

    4. Roy, R., Pal, D., Sur, S., et al. Pongapin and Karanjin, furanoflavanoids of Pongamia pinnata, induce G2/M arrest and apoptosis in cervical cancer cells by differential reactive oxygen species modulation, DNA damage, and nuclear factor kappa-light-chain-enhancer of activated B cell signaling. Phytother. Res. 33(4), 1084-1094 (2019).

    5. Ma, Q., Li, C., Lin, G., et al. Karanjin counteracts OVX-induced bone loss by dual regulating bone remodeling. Phytomedicine 146, 157099 (2025).