A peptide fragment of proinsulin
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

C-Peptide

Item No. 44549

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-α-glutamyl-L-alanyl-L-α-glutamyl-L-α-aspartyl-L-leucyl-L-glutaminyl-L-valylglycyl-L-glutaminyl-L-valyl-L-α-glutamyl-L-leucylglycylglycylglycyl-L-prolylglycyl-L-alanylglycyl-L-seryl-L-leucyl-L-glutaminyl-L-prolyl-L-leucyl-L-alanyl-L-leucyl-L-α-glutamylglycyl-L-seryl-L-leucyl-L-glutamine
CAS Number
33017-11-7
Molecular Formula
C129H211N35O48
Formula Weight
3020.3
Purity
≥95%
Formulation (Request formulation change)
A solid
Peptide Sequence
H-EAEDLQVGQVELGGGPGAGSLQPLALEGSLQ-OH
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥ 10 mg/ml
SMILES
O=C(O)CC[C@H](N[H])C(N[C@H](C(N[C@@H](CCC(O)=O)C(N[C@@H](CC(O)=O)C(N[C@H](C(N[C@@H](CCC(N[H])=O)C(N[C@@H](C(C)C)C(NCC(N[C@@H](CCC(N[H])=O)C(N[C@@H](C(C)C)C(N[C@@H](CCC(O)=O)C(N[C@H](C(NCC(NCC(NCC(N1CCC[C@H]1C(NCC(N[C@H](C(NCC(N[C@@H](CO[H])C(N[C@H](C(N[C@@H](CCC(N[H])=O)C(N2CCC[C@H]2C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CCC(O)=O)C(NCC(N[C@@H](CO[H])C(N[C@H](C(N[C@@H](CCC(N[H])=O)C(O)=O)=O)CC(C)C)=O)=O)=O)=O)CC(C)C)=O)C)=O)CC(C)C)=O)=O)=O)CC(C)C)=O)=O)=O)C)=O)=O)=O)=O)=O)=O)CC(C)C)=O)=O)=O)=O)=O)=O)=O)CC(C)C)=O)=O)=O)C)=O
InChi Code
InChI=1S/C129H211N35O48/c1-58(2)42-77(155-113(195)74(31-39-102(184)185)151-127(209)105(65(15)16)162-114(196)71(25-32-88(131)167)145-95(174)54-141-126(208)104(64(13)14)161-115(197)72(26-33-89(132)168)150-118(200)80(45-61(7)8)156-121(203)83(48-103(186)187)159-112(194)73(30-38-101(182)183)148-107(189)67(18)143-109(191)69(130)24-36-99(178)179)111(193)138-50-93(172)135-49-92(171)136-55-98(177)163-40-20-22-86(163)124(206)140-51-94(173)142-66(17)106(188)137-52-96(175)146-84(56-165)122(204)157-81(46-62(9)10)119(201)152-75(27-34-90(133)169)128(210)164-41-21-23-87(164)125(207)160-78(43-59(3)4)116(198)144-68(19)108(190)154-79(44-60(5)6)117(199)149-70(29-37-100(180)181)110(192)139-53-97(176)147-85(57-166)123(205)158-82(47-63(11)12)120(202)153-76(129(211)212)28-35-91(134)170/h58-87,104-105,165-166H,20-57,130H2,1-19H3,(H2,131,167)(H2,132,168)(H2,133,169)(H2,134,170)(H,135,172)(H,136,171)(H,137,188)(H,138,193)(H,139,192)(H,140,206)(H,141,208)(H,142,173)(H,143,191)(H,144,198)(H,145,174)(H,146,175)(H,147,176)(H,148,189)(H,149,199)(H,150,200)(H,151,209)(H,152,201)(H,153,202)(H,154,190)(H,155,195)(H,156,203)(H,157,204)(H,158,205)(H,159,194)(H,160,207)(H,161,197)(H,162,196)(H,178,179)(H,180,181)(H,182,183)(H,184,185)(H,186,187)(H,211,212)/t66-,67-,68-,69-,70-,71-,72-,73-,74-,75-,76-,77-,78-,79-,80-,81-,82-,83-,84-,85-,86-,87-,104-,105-/m0/s1
InChi Key
VOUAQYXWVJDEQY-QENPJCQMSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    500 µg

    $185

    Add

    1 mg

    $315

    Add

    5 mg

    $833

    Add
    Cayman Chemical
    Explore Obesity & Metabolic Disease Resources

    Discover high-quality research tools to investigate GLP-1 mechanisms and next-generation metabolic targets.

    OBESITY RESEARCH SOLUTIONS
    Product Description

    C-peptide is a peptide fragment corresponding to residues of 57-78 of proinsulin.1 It is a cleavage product of insulin and is co-secreted from pancreatic β cells with insulin in response to glucose stimulation. C-peptide increases AMP-activated protein kinase α (AMPKα) phosphorylation and inhibits ROS-mediated apoptosis in glucose-stimulated human umbilical vein endothelial cells (HUVECs) and increases nitric oxide (NO) levels in isolated rat aorta segments.2,3 It reduces initial glomerular hyperfiltration and increases the glomerular filtration rate after glycine infusion in a rat model of diabetic nephropathy induced by streptozotocin (STZ; Item No. 13104).4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ido, Y., Vindigni, A., Chang, K., et al. Prevention of vascular and neural dysfunction in diabetic rats by C-peptide. Science 277(5325), 563-566 (1997).

    2. Bhatt, M.P., Lim, Y.-C., Kim, Y.-M., et al. C-peptide activates AMPKα and prevents ROS-mediated mitochondrial fission and endothelial apoptosis in diabetes. Diabetes 62(11), 3851-3862 (2013).

    3. Scalia, R., Coyle, K.M., Levine, B.J., et al. C-peptide inhibits leukocyte-endothelium interaction in the microcirculation during acute endothelial dysfunction. The FASEB Journal 14(14), 2357-2364 (2000).

    4. Samnegård, B., Jacobson, S.H., Jaremko, G., et al. Effects of C-peptide on glomerular and renal size and renal function in diabetic rats. Kidney Int. 60(4), 1258-1265 (2001).