A multivalent GalNAc-conjugated lipid
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DSPE-PEG(2000)-tri-GalNAc

Item No. 44551

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-((((39-(((2R,3R,4R,5R,6R)-3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-24,24-bis((3-((3-(5-(((2R,3R,4R,5R,6R)-3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)pentanamido)propyl)amino)-3-oxopropoxy)methyl)-4,13,17,22,29,35-hexaoxo-5,8,26-trioxa-3,12,18,23,30,34-hexaazanonatriacontyl)oxy)(hydroxy)phosphoryl)oxy)propane-1,2-diyl distearate
Molecular Formula
(C2H4O)nC115H210N13O40P
Formulation (Request formulation change)
A semi-solid
Solubility(Learn about Variance in Solubility)
Chloroform: solubleDMSO: solubleEthanol: solubleWater: soluble
SMILES
O=C(NCCCNC(CCOCC(NC(CCCNC(CCCC(NCCCOCCOC(NCCOP(OCC(OC(CCCCCCCCCCCCCCCCC)=O)COC(CCCCCCCCCCCCCCCCC)=O)(O)=O)=O)=O)=O)=O)(COCCC(NCCCNC(CCCCO[C@H](O[C@H](CO)[C@@H]1O)[C@H](NC(C)=O)[C@H]1O)=O)=O)COCCC(NCCCNC(CCCCO[C@@H]([C@@H]2NC(C)=O)O[C@@H]([C@@H]([C@@H]2O)O)CO)=O)=O)=O)CCCCO[C@@H]([C@@H]3NC(C)=O)O[C@@H]([C@@H]([C@@H]3O)O)CO
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    100 µg

    $109

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    250 µg

    $218

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    Cayman Chemical
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    Product Description

    DSPE-PEG(2000)-tri-GalNAc is a multivalent N-acetylgalactosamine-conjugated lipid composed of an O-deacetylated derivative of LNP GalNAc ligand 1 (Item No. 38952), a GABA linker, a PEG(2000) spacer, and 1,2-distearoyl-rac-glycero-3-phosphoethanolamine. Multivalent GalNAc-conjugated lipids have been used in the generation of lipid nanoparticles (LNPs) for targeted liver delivery via the asialoglycoprotein receptor (ASGPR).1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kasiewicz, L.N., Biswas, S., Beach, A., et al. GalNAc-Lipid nanoparticles enable non-LDLR dependent hepatic delivery of a CRISPR base editing therapy. Nat. Commun. 14(1), 2776 (2023).