A PEGylated and mannosylated form of DSPE
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DSPE-PEG(2000)-Mannose

Item No. 44722

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
α-[(9R)-6-hydroxy-6-oxido-1,12-dioxo-9-[(1-oxooctadecyl)oxy]-5,7,11-trioxa-2-aza-6-phosphanonacos-1-yl]-ω-[2-[[[[4-(α-D-mannopyranosyloxy)phenyl]amino]thioxomethyl]amino]ethoxy]-poly(oxy-1,2-ethanediyl)
CAS Number
1829524-73-3
Synonyms
  • 1,2-Distearoyl-sn-glycero-3-PE-Polyethylene Glycol-2000-Mannose
  • 1,2-Distearoyl-sn-glycero-3-Phosphoethanolamine-Polyethylene Glycol-2000-Mannose
  • DSPE-PEG2000-Mannose
  • 1,2-DSPE-PEG(2000)-Mannose
Molecular Formula
(C2H4O)nC57H102N3O16PS
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Slightly soluble: 0.1-1 mg/mlEthanol: Sparingly soluble: 1-10 mg/mlPBS (pH 7.2): Slightly soluble: 0.1-1 mg/ml
SMILES
O=C(NCCOP(O)(OC[C@@H](COC(CCCCCCCCCCCCCCCCC)=O)OC(CCCCCCCCCCCCCCCCC)=O)=O)OCCOCCNC(NC1=CC=C(O[C@@H]2[C@@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O2)C=C1)=S
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

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    10 mg

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    Cayman Chemical
    Learn More About Leveraging Helper Lipids to Achieve Versatile LNPs
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    Product Description

    DSPE-PEG(2000)-mannose is a PEGylated and mannosylated form of 1,2-distearoyl-sn-glycero-3-PE (1,2-DSPE; Item No. 15095) that has been used in the generation of liposomes and lipid nanoparticles (LNPs) for the delivery of peptides, oligodeoxynucleotides, and siRNA in vitro and in vivo.1,2 Fluorescently labeled LNPs containing DSPE-PEG(2000)-mannose selectively accumulate in the liver and spleen over the brain, lungs, heart, kidney, and pancreas in mice.1 Immunization with liposomes containing DSPE-PEG(2000)-mannose and encapsulating human papilloma virus type 16 (HPV16) E7 peptide and CpG oligodeoxynucleotide as an adjuvant decrease tumor size, intratumoral CD4+ or CD8+ T cells, and intratumoral angiogenesis in a murine lung cancer model using TC-1 cells, which express HPV16 E6 and E7 peptides.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Yeo, S., Lee, H., Lee, J., et al. Optimization of polyethylene glycol shielding and mannose density on the lipid nanoparticles for efficient delivery to macrophages and spleens. Int. J. Pharm. 662, 124540 (2024).

    2. Zhao, Y., Wang, H., Yang, Y., et al. Mannose-modified liposome co-delivery of human papillomavirus type 16 E7 peptide and CpG oligodeoxynucleotide adjuvant enhances antitumor activity against established large TC-1 grafted tumors in mice. Int. J. Nanomedicine 15, 9571-9586 (2020).