An antagonist of GHS-R1a
Related Products
Alternative(s)
29217YIL 781 (hydrochloride)
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

YIL 781

Item No. 45211

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(S)-6-(4-fluorophenoxy)-3-((1-isopropylpiperidin-3-yl)methyl)-2-methylquinazolin-4(3H)-one
CAS Number
875258-85-8
Molecular Formula
C24H28FN3O2
Formula Weight
409.5
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: Slightly soluble: 0.1-1 mg/ml
SMILES
FC1=CC=C(OC2=CC=C(N=C(C)N(C[C@H]3CCCN(C(C)C)C3)C4=O)C4=C2)C=C1
InChi Code
InChI=1S/C24H28FN3O2/c1-16(2)27-12-4-5-18(14-27)15-28-17(3)26-23-11-10-21(13-22(23)24(28)29)30-20-8-6-19(25)7-9-20/h6-11,13,16,18H,4-5,12,14-15H2,1-3H3/t18-/m0/s1
InChi Key
FRKXOBMDEXCHHD-SFHVURJKSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    5 mg

    $112

    Add

    10 mg

    $179

    Add

    25 mg

    $392

    Add

    50 mg

    $728

    Add
    Cayman Chemical
    Explore Obesity & Metabolic Disease Resources

    Discover high-quality research tools to investigate GLP-1 mechanisms and next-generation metabolic targets.

    OBESITY RESEARCH SOLUTIONS
    Product Description

    YIL 781 is an antagonist of growth hormone secretagogue receptor 1a (GHS-Ra; Ki = 0.017 µM).1 It is selective for GHS-Ra over the motilin receptor (Ki = 6 µM) and a panel of 30 receptors and enzymes (Kis = > 10 µM). YIL 781 (1 µM) prevents ghrelin-induced decreases in insulin secretion in glucose-stimulated isolated rat pancreatic islets. It increases plasma insulin levels and decreases blood glucose levels in an intraperitoneal glucose tolerance test in rats when administered at doses of 0.3 or 10 mg/kg, respectively. YIL 781 (10 and 20 mg/kg) inhibits cocaine-induced hyperlocomotion in mice.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Esler, W.P., Rudolph, J., Claus, T.H., et al. Small-molecule ghrelin receptor antagonists improve glucose tolerance, suppress appetite, and promote weight loss. Endocrinology 148(11), 5175-5185 (2007).

    2. Toth, K., Slosky, L.M., Pack, T.F., et al. Ghrelin receptor antagonism of hyperlocomotion in cocaine-sensitized mice requires βarrestin-2. Synapse 72(1), e22012 (2018).