A derivative of BPA
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Bisphenol S

Item No. 45556

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4,4′-sulfonylbis-phenol
CAS Number
80-09-1
Synonyms
  • Bis(4-hydroxyphenyl)sulfone
  • BPS
  • NSC 683541
  • NSC 8712
  • 4,4′-Sulfonyldiphenol
Molecular Formula
C12H10O4S
Formula Weight
250.3
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥10 mg/mlEthanol: Soluble: ≥10 mg/ml
SMILES
O=S(C1=CC=C(C=C1)O)(C2=CC=C(C=C2)O)=O
InChi Code
InChI=1S/C12H10O4S/c13-9-1-5-11(6-2-9)17(15,16)12-7-3-10(14)4-8-12/h1-8,13-14H
InChi Key
VPWNQTHUCYMVMZ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    100 mg

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    250 mg

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    500 mg

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    1 g

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    Cayman Chemical
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    Product Description

    Bisphenol S (BPS) is a derivative of bisphenol A (BPA), an environmental contaminant, and an endocrine disruptor.1,2 It has been detected in surface water and sewage effluent and in personal care products, paper, and food.3 BPS increases estrogenic activity in vitro, in female rats, and in male and female zebrafish. It decreases testosterone levels in male zebrafish and impairs testicular development in male offspring after maternal exposure in rats.2,3 BPS also has neurotoxic effects, decreasing viability of SK-N-SH cells and primary rat hippocampal neurons, among other cell types.1 It reduces dendritic length and branching in mice and increases anxiety and impairs learning and memory in rats. BPS increases serum levels of LDL cholesterol and non-esterified fatty acids (NEFA) and induces hepatic lipid accumulation in mice when administered at a dose of 1 mg/kg per day for three months.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Cantua, R., and Mulligan, K. Developmental neurotoxicity of bisphenol F and bisphenol S in animal model systems: A literature review. Neurotoxicology 108, 263-280 (2025).

    2. Li, B., Tian, Y., Wu, X., et al. Maternal bisphenol S exposure impairs testicular development and sperm function in male offspring by disrupting the immune-endocrine network. Small e13075 (2026).

    3. Rochester, J.R., and Bolden, A.L. Bisphenol S and F: A systematic review and comparison of the hormonal activity of bisphenol A substitutes. Environ. Health Perspect. 123(7), 643-650 (2015).

    4. Li, S., Fan, Y., Tang, M., et al. Bisphenol S exposure and MASLD: A mechanistic study in mice. Environ. Health Perspect. 133(5), 57009 (2025).