An internal standard for the quantification of campesterol
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Unlabeled Version(s)
41695Campesterol
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Campesterol-d7

Item No. 45690

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(3β,24ξ)-ergost-5-en-25,26,26,26,27,27,27-d7-3-ol
CAS Number
2483832-11-5
Molecular Formula
C28H41D7O
Formula Weight
407.7
Purity
≥99% deuterated forms (d1-d7)
Formulation (Request formulation change)
A 1 mg/ml solution in ethyl acetate
Solubility(Learn about Variance in Solubility)
Ethyl Acetate: Soluble
SMILES
C[C@@]12[C@](CC[C@]2([H])[C@@H](CCC(C)C(C([2H])([2H])[2H])([2H])C([2H])([2H])[2H])C)([H])[C@@]3([H])[C@@](CC1)([H])[C@@]4(C(C[C@H](CC4)O)=CC3)C
InChi Code
InChI=1S/C28H48O/c1-18(2)19(3)7-8-20(4)24-11-12-25-23-10-9-21-17-22(29)13-15-27(21,5)26(23)14-16-28(24,25)6/h9,18-20,22-26,29H,7-8,10-17H2,1-6H3/t19?,20-,22+,23+,24-,25+,26+,27+,28-/m1/s1/i1D3,2D3,18D
InChi Key
SGNBVLSWZMBQTH-IMAWIAHVSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    Product Description

    Campesterol-d7 is intended for use as an internal standard for the quantification of campesterol (Item No. 41695) by GC- or LC-MS. Campesterol is a phytosterol that has been found in D. innoxia and has diverse biological activities.1,2,3,4 It inhibits basic FGF-induced proliferation in, and vessel formation by, human umbilical vein endothelial cells (HUVECs) when used at concentrations of 1, 5, or 10 µM.2 Campesterol (15 µM) decreases the proliferation of MCF-7 and ZR-75-1 breast cancer cells.3 It reduces the levels of estrogen receptor α (ERα) in, and the diameter of, patient-derived breast cancer organoids when used at a concentration of 10 µM. Campesterol has been used as a marker of cholesterol intestinal absorption in humans.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ramadan, M.F., Zayed, R., and El-Shamy, H. Screening of bioactive lipids and radical scavenging potential of some solanaceae plants. Food Chem. 103(3), 885-890 (2007).

    2. Choi, J.M., Lee, E.O., Lee, H.J., et al. Identification of campesterol from Chrysanthemum coronarium L. and its antiangiogenic activities. Phytother. Res. 21(10), 954-959 (2007).

    3. Majumder, R., Banerjee, S., Mandal, M., et al. A virtual drug discovery screening illuminates campesterol as a potent estrogen receptor alpha inhibitor in breast cancer. J. Med. Chem. 67(12), 10321-10335 (2024).

    4. Wu, A.H., Ruan, W., Todd, J., et al. Biological variation of β-sitosterol, campesterol, and lathosterol as cholesterol absorption and synthesis biomarkers. Clin. Chim. Acta 430, 43-47 (2014).