A PEGylated and maleimide-functionalized form of cholesterol
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Cholesterol-PEG(2000)-Maleimide

Item No. 45804

Product Insert (PDF)
Technical Information
Formal Name
(3S,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-17-((R)-6-methylheptan-2-yl)-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl (2-(2-(3-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)propanamido)ethoxy)ethyl)carbamate
Synonyms
  • Cholesterol-PEG2000-Maleimide
Molecular Formula
(C2H4O)nC37H57N3O5
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥10 mg/mlEthanol: Soluble: ≥10 mg/mlPBS pH 7.2: Sparingly soluble: 1-10 mg/ml
SMILES
O=C(NCCOCCNC(O[C@H](CC1=CC[C@@]2([H])[C@]3([H])CC[C@@]([C@@H](CCCC(C)C)C)([H])[C@@]3(C)CC[C@]42[H])CC[C@@]14C)=O)CCN5C(C=CC5=O)=O
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $50

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    10 mg

    $95

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    25 mg

    $150

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    Cayman Chemical
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    Product Description

    Cholesterol-PEG(2000)-maleimide is a PEGylated form of cholesterol (Item Nos. 9003100 | 39088 | 39448) that contains maleimide, which can react with the thiol group in cysteine residues to form a stable thioether bond.1 It has been used to anchor an α2-antiplasmin (α2-AP) peptide to perfluorocarbon (PFC) nanoemulsions for use as thrombus-targeted contrast agents in a mouse model of pulmonary thromboembolism.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Temme, S., Grapentin, C., Quast, C., et al. Noninvasive imaging of early venous thrombosis by 19F magnetic resonance imaging with targeted perfluorocarbon nanoemulsions. Circulation 131(16), 1405-1414 (2015).