A previously proposed metabolite of repaglinide
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3-hydroxy Repaglinide

Item No. 45941

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-ethoxy-4-[2-[[1-[2-(3-hydroxy-1-piperidinyl)phenyl]-3-methylbutyl]amino]-2-oxoethyl]-benzoic acid
CAS Number
874908-14-2
Molecular Formula
C27H36N2O5
Formula Weight
468.6
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: Slightly soluble: 0.1-1 mg/ml
SMILES
CC(CC(NC(CC1=CC=C(C(O)=O)C(OCC)=C1)=O)C2=C(C=CC=C2)N3CC(CCC3)O)C
InChi Code
InChI=1S/C27H36N2O5/c1-4-34-25-15-19(11-12-22(25)27(32)33)16-26(31)28-23(14-18(2)3)21-9-5-6-10-24(21)29-13-7-8-20(30)17-29/h5-6,9-12,15,18,20,23,30H,4,7-8,13-14,16-17H2,1-3H3,(H,28,31)(H,32,33)
InChi Key
OBMAZJVHPAVADF-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

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    OBESITY RESEARCH SOLUTIONS
    Product Description

    3-hydroxy Repaglinide is a previously proposed metabolite of repaglinide (Item No. 19387).1 It was previously proposed to be a metabolite formed by the cytochrome P450 (CYP) isoform CYP2C8, but it was later shown that CYP2C8 metabolizes repaglinide to 4-hydroxy repaglinide.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Sharma, R., Balesano, A., Doran, A.C., et al. Human cytochrome P4502C8 metabolizes repaglinide to 4'-hydroxyrepaglinide, not 3'-hydroxyrepaglinide. Drug Metab. Dispos. 53(11), 100177 (2025).