An antagonist of MCH1
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AZD 1979

Item No. 45989

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
[5-(4-methoxyphenyl)-1,3,4-oxadiazol-2-yl][3-[4-(2-oxa6-azaspiro[3.3]hept-6-ylmethyl)phenoxy]-1-azetidinyl]-methanone
CAS Number
1254035-84-1
Molecular Formula
C25H26N4O5
Formula Weight
462.5
Purity
≥98%
Formulation (Request formulation change)
A solid
SMILES
COC1=CC=C(C2=NN=C(C(N3CC(C3)OC(C=C4)=CC=C4CN5CC6(C5)COC6)=O)O2)C=C1
InChi Code
InChI=1S/C25H26N4O5/c1-31-19-8-4-18(5-9-19)22-26-27-23(34-22)24(30)29-11-21(12-29)33-20-6-2-17(3-7-20)10-28-13-25(14-28)15-32-16-25/h2-9,21H,10-16H2,1H3
InChi Key
BKKPIQPFRAPEAY-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $165

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    10 mg

    $264

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    25 mg

    $495

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    50 mg

    $825

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    Cayman Chemical
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    Product Description

    AZD 1979 is an antagonist of melanin-concentrating hormone receptor 1 (MCH1; IC50 = 11 nM).1 It is selective for MCH1 over human-ether-a-go-go (hERG) and MCH2 (IC50s = 22 and >40 µM, respectively). AZD 1979 (60 µmol/kg, p.o.) reduces food intake and body weight in wild-type but not Mchr1 knockout mice in a model of diet-induced obesity.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Johansson, A., Löfberg, C., Antonsson, M., et al. Discovery of (3-(4-(2-oxa-6-azaspiro[3.3]heptan-6-ylmethyl)phenoxy)azetidin-1-yl)(5-(4-methoxyphenyl)-1,3,4-oxadiazol-2-yl)methanone (AZD1979), a melanin concentrating hormone receptor 1 (MCHr1) antagonist with favorable physicochemical properties. J. Med. Chem. 59(6), 2497-2511 (2016).

    2. Ploj, K., Benthem, L., Kakol-Palm, D., et al. Effects of a novel potent melanin-concentrating hormone receptor 1 antagonist, AZD1979, on body weight homeostasis in mice and dogs. Br. J. Pharmacol. 173(18), 2739-2751 (2016).