A PEGylated and TCO-functionalized form of DSPE
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Unmodified Version(s)
34652DSPE-mPEG(5000) (sodium salt)43359DSPE-MPEG(5000)
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DSPE-PEG(5000)-TCO

Item No. 46430

Product Insert (PDF)
Technical Information
Formal Name
(2R)-3-((((1-(((R,E)-cyclooct-4-en-1-yl)oxy)-1,10-dioxo-5,8-dioxa-2,11-diazatridecan-13-yl)oxy)(hydroxy)phosphoryl)oxy)propane-1,2-diyl distearate
Synonyms
  • 1,2-Distearoyl-sn-glycero-3-Phosphoethanolamine-Polyethylene Glycol-5000-trans-cyclooctene
  • DSPE-PEG5k-TCO
Molecular Formula
(C2H4O)nC54H101N2O12P
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥10 mg/ml
SMILES
CCCCCCCCCCCCCCCCCC(OC[C@H](COP(O)(OCCNC(COCCOCCNC(O[C@@H]1CCC/C=C/CC1)=O)=O)=O)OC(CCCCCCCCCCCCCCCCC)=O)=O
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    5 mg

    $195

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    10 mg

    $371

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    Cayman Chemical
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    Product Description

    DSPE-PEG(5000)-TCO is a PEGylated derivative of 1,2-distearoyl-sn-glycero-3-phosphoethanolamine (1,2-DSPE; Item No. 15095) that contains a trans-cyclooctene (TCO) moiety.1,2 It has been used in the bioorthogonal ligation of liposomes to macrophages.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Cheng, J., Gao, R., Lyu, Y., et al. Homotransplantation of engineered macrophages with surface-modified nanomedicines for mitigating myocardial ischemia-reperfusion injury. ACS Nano 19(27), 25069-25087 (2025).

    2. Tan, H., Li, W., Pang, Z., et al. Genetically engineered macrophages co-loaded with CD47 inhibitors synergistically reconstruct efferocytosis and improve cardiac remodeling post myocardial ischemia reperfusion injury. Adv. Healthc. Mater. 13(16), e2303267 (2024).