A PEGylated and clickable form of DSPE
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DSPE-PEG(5000)-tetrazine

Item No. 46431

Product Insert (PDF)
Technical Information
Formal Name
(2R)-3-((((14-(4-(1,2,4,5-tetrazin-3-yl)phenyl)-4,13-dioxo-6,9-dioxa-3,12-diazatetradecyl)oxy)(hydroxy)phosphoryl)oxy)propane-1,2-diyl distearate
Synonyms
  • DSPE-PEG5k-Tre
  • DSPE-PEG(5000)-Tz
Molecular Formula
(C2H4O)nC55H95N6O11P
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥10 mg/ml
SMILES
CCCCCCCCCCCCCCCCCC(O[C@@H](COP(OCCNC(COCCOCCNC(CC(C=C1)=CC=C1C2=NN=CN=N2)=O)=O)(O)=O)COC(CCCCCCCCCCCCCCCCC)=O)=O
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

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    5 mg

    $139

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    10 mg

    $264

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    Cayman Chemical
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    Product Description

    DSPE-PEG(5000)-tetrazine is a PEGylated and clickable form of 1,2-distearoyl-sn-glycero-3-PE (1,2-DSPE; Item No. 15095) that has been used as a reactive anchor lipid by direct incorporation into the plasma membranes of CD8+ T cells.1 DSPE-PEG(5000)-tetrazine, via membrane incorporation, has been used to conjugate T cells to liposomes containing DSPE-bicyclo[6.1.0]nonyne (DSPE-BCN) and encapsulating avasimibe (Item No. 18129) for tumor immunotherapy in mice.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Hao, M., Hou, S., Li, W., et al. Combination of metabolic intervention and T cell therapy enhances solid tumor immunotherapy. Sci. Transl. Med. 12(571), eaaz6667 (2020).