A synthetic caffeamide derivative
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KS370G

Item No. 46450

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-(3,4-dihydroxyphenyl)-N-(2-phenylethyl)-2-propenamide
CAS Number
105955-01-9
Synonyms
  • Caffeic Acid phenylethyl amide
  • Caffeoylphenethylamine
  • CFPA
Molecular Formula
C17H17NO3
Formula Weight
283.3
Purity
≥98%
Formulation (Request formulation change)
A solid
SMILES
OC1=CC(C=CC(NCCC2=CC=CC=C2)=O)=CC=C1O
InChi Code
InChI=1S/C17H17NO3/c19-15-8-6-14(12-16(15)20)7-9-17(21)18-11-10-13-4-2-1-3-5-13/h1-9,12,19-20H,10-11H2,(H,18,21)
InChi Key
QOWABIXYAFJMQE-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $25

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    5 mg

    $69

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    10 mg

    $113

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    25 mg

    $219

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    Cayman Chemical
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    Product Description

    KS370G is a synthetic caffeamide and the amide-containing derivative of caffeic acid phenylethyl ester (Item No. 70750).1,2,3,4 It inhibits matrix metalloproteinase-2 (MMP-2) and MMP-9 (IC50s = 8.2 and 7.28 nM, respectively) and has antioxidant activity in cell-free assays.5,6 KS370G inhibits viral replication in porcine alveolar macrophages infected with porcine reproductive and respiratory syndrome virus (PRRSV).7 It decreases LPS- and IFN-γ-induced production of nitric oxide (NO) and prostaglandin E2 (PGE2; Item No. 14010) in BV-2 microglia at 0.35-3.5 µM.1 KS370G decreases left ventricular hypertrophy and reverses left ventricular function impairments induced by abdominal aortic constriction in mice.2 It also decreases plasma glucose levels and increases plasma insulin levels in normal and diabetic mice.3 Additionally, KS370G (10 mg/kg) decreases renal fibrosis in a mouse model of renal ischemia-reperfusion injury.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Lu, D.Y., Huang, B.R., Yeh, W.L., et al. Anti-neuroinflammatory effect of a novel caffeamide derivative, KS370G, in microglial cells. Mol. Neurobiol. 48(3), 863-874 (2013).

    2. Weng, Y.C., Chuang, C.F., Chuang, S.T., et al. KS370G, a synthetic caffeamide derivative, improves left ventricular hypertrophy and function in pressure-overload mice heart. Eur. J. Pharmacol. 684(1-3), 108-115 (2012).

    3. Weng, Y.C., Chiu, H.L., Lin, Y.C., et al. Antihyperglycemic effect of a caffeamide derivative, KS370G, in normal and diabetic mice. J. Agric. Food Chem. 58(18), 10033-10038 (2010).

    4. Chuang, S.T., Kuo, Y.H., and Su, M.J. Antifibrotic effects of KS370G, a caffeamide derivative, in renal ischemia-reperfusion injured mice and renal tubular epithelial cells. Sci. Rep. 4, 5814 (2014).

    5. Shi, Z.H., Li, N.G., Shi, Q.P., et al. Synthesis and structure–activity relationship analysis of caffeic acid amides as selective matrix metalloproteinase inhibitors. Bioorg. Med. Chem. Lett. 23(5), 1206-1266 (2013).

    6. Yang, Y., Song, Z.-G., and Liu, Z.-Q. Synthesis and antioxidant capacities of hydroxyl derivatives of cinnamoylphenethylamine in protecting DNA and scavenging radicals. Free Radic. Res. 45(4), 445-453 (2011).

    7. He, Z., Nie, Z., Liao, J., et al. Identification of compounds targeting porcine reproductive and respiratory syndrome virus nsp3 and evaluation of their antiviral efficacy. Virulence 16(1), 2530176 (2025).