An aldose reductase inhibitor
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WJ-39

Item No. 46467

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-[(2,3-dichlorophenyl)methyl]-6-methoxy-4-oxo-1(4H)-quinolineacetic acid, monopotassium salt
CAS Number
3009908-95-3
Molecular Formula
C19H14Cl2NO4 • K
Formula Weight
430.3
Purity
≥98%
Formulation (Request formulation change)
A solid
SMILES
O=C(CN1C=C(CC2=C(Cl)C(Cl)=CC=C2)C(C3=CC(OC)=CC=C31)=O)[O-].[K+]
InChi Code
InChI=1S/C19H15Cl2NO4.K/c1-26-13-5-6-16-14(8-13)19(25)12(9-22(16)10-17(23)24)7-11-3-2-4-15(20)18(11)21;/h2-6,8-9H,7,10H2,1H3,(H,23,24);/q;+1/p-1
InChi Key
KOVHOMQLMHEHRB-UHFFFAOYSA-M
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $49

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    5 mg

    $147

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    10 mg

    $270

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    25 mg

    $429

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    Cayman Chemical
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    OBESITY RESEARCH SOLUTIONS
    Product Description

    WJ-39 is an inhibitor of aldose reductase.1,2 It reduces high glucose-induced increases in mitochondrial reactive oxygen species (ROS) production and apoptosis in HK-2 kidney epithelial cells.2 WJ-39 (20-40 mg/kg) reduces renal aldose reductase activity, increases renal mitophagy, and rescues renal tubule morphology in a rat model of diabetic nephropathy induced by streptozotocin (Item No. 13104) and a high-fat diet.1,2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Zhou, X., Liu, Z., Ying, K., et al. WJ-39, an aldose reductase inhibitor, ameliorates renal lesions in diabetic nephropathy by activating Nrf2 signaling. Oxid. Med. Cell. Longev. 7950457 (2020).

    2. Yang, L., Xu, L., Hao, X., et al. An aldose reductase inhibitor, WJ-39, ameliorates renal tubular injury in diabetic nephropathy by activating PINK1/Parkin signaling. Eur. J. Pharmacol. 967, 176376 (2024).