A CYP11A1 inhibitor
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Opevesostat

Item No. 46501

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[(1,3-dihydro-2H-isoindol-2-yl)methyl]-5-[[1-(methylsulfonyl)-4-piperidinyl]methoxy]-4H-pyran-4-one
CAS Number
2231294-96-3
Synonyms
  • MK-5684
  • ODM-208
Molecular Formula
C21H26N2O5S
Formula Weight
418.5
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥ 10 mg/ml
SMILES
O=C1C=C(CN2CC3=C(C2)C=CC=C3)OC=C1OCC4CCN(S(=O)(C)=O)CC4
InChi Code
InChI=1S/C21H26N2O5S/c1-29(25,26)23-8-6-16(7-9-23)14-28-21-15-27-19(10-20(21)24)13-22-11-17-4-2-3-5-18(17)12-22/h2-5,10,15-16H,6-9,11-14H2,1H3
InChi Key
LHVKCOBGLZGRQZ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    5 mg

    $75

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    10 mg

    $128

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    25 mg

    $244

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    50 mg

    $375

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    Product Description

    Opevesostat is an inhibitor of the cytochrome P450 (CYP) isoform CYP11A1 (IC50 = 20.4 nM), the enzyme that catalyzes the first committed step of steroid hormone biosynthesis by converting cholesterol (Item Nos. 9003100 | 39088 | 39448) to pregnenolone (Item No. 19864).1 It is selective for CYP11A1 over CYP1A2, CYP2C9, CYP2C19, CYP2D6, and CYP3A4/5 at 10 µM.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Wang, D., Cui, S., Yuan, J., et al. Design, synthesis, and biological evaluation of cytochrome P450 CYP11A1 inhibitors. Bioorg. Med. Chem. 135, 130567 (2026).