An mTOR inhibitor
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P-2281

Item No. 46503

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-chloro-N-(6-cyano-3-pyridinyl)-propanamide
CAS Number
1112994-35-0
Molecular Formula
C9H8ClN3O
Formula Weight
209.6
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly soluble: 1-10 mg/mlEthanol: Sparingly soluble: 1-10 mg/ml
SMILES
N#CC1=NC=C(NC(C(C)Cl)=O)C=C1
InChi Code
InChI=1S/C9H8ClN3O/c1-6(10)9(14)13-8-3-2-7(4-11)12-5-8/h2-3,5-6H,1H3,(H,13,14)
InChi Key
VFOLQYOVUCHHET-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $45

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    5 mg

    $158

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    10 mg

    $225

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    25 mg

    $394

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    Product Description

    P-2281 is an mTOR inhibitor.1 It inhibits serum-induced phosphorylation of p70 ribosomal S6 kinase 1 (p70S6K1) in serum-starved HCT116 colon cancer cells at 30 µM and serum-induced phosphorylation of 4E-BP1 in serum-starved H460 non-small cell lung cancer (NSCLC) cells at 3 or 10 µM. P-2281 (30 µM) reduces concanavalin A-induced IFN-γ production but not LPS-induced TNF-α production in isolated human peripheral blood mononuclear cells (PBMCs). It decreases disease severity in a mouse model of colitis induced by dextran sulfate sodium (DSS) at 15 mg/kg.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Bhonde, M.R., Gupte, R.D., Dadarkar, S.D., et al. A novel mTOR inhibitor is efficacious in a murine model of colitis. Am. J. Physiol. Gastrointest. Liver Physiol. 295(6), G1237-G1245 (2008).