An irreversible, non-selective inhibitor of COX-1 and COX-2
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O-Acetyl Salicylhydroxamic Acid

Item No. 70263

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-(acetyloxy)-2-hydroxy benzamide
CAS Number
199854-00-7
Synonyms
  • AcSHA
  • O-ASHA
Molecular Formula
C9H9NO4
Formula Weight
195.2
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 50 mg/mlEthanol: 25 mg/mlPBS (pH 7.2): .2 mg/ml
SMILES
CC(=O)ONC(=O)c1ccccc1O
InChi Code
InChI=1S/C9H9NO4/c1-6(11)14-10-9(13)7-4-2-3-5-8(7)12/h2-5,12H,1H3,(H,10,13)
InChi Key
PCFWLDHLJWUGSU-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $21

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    5 mg

    $86

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    10 mg

    $152

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    50 mg

    $655

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    Product Description

    O-Acetyl Salicylhydroxamic Acid (O-ASHA) is an irreversible, non-selective inhibitor of COX-1 and COX-2. Aspirin is the best-studied example of an irreversible COX inhibitor, acting via the acetylation of the active site serine residue 529 in human COX-1. O-ASHA inhibits ovine COX-1 in a time-dependent, irreversible manner with a 50% B/B0 value of approximately 4.5 mM.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Loll, P.J., Sharkey, C.T., O'Connor, S.J., et al. O-acetylsalicylhydroxamic acid, a novel acetylating inhibitor of prostaglandin H2 synthase: structural and functional characterization of enzyme-inhibitor interactions. Mol. Pharmacol. 60(6), 1407-1413 (2001).