A CB2 receptor inverse agonist
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IMMA

Item No. 70275

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]-1-(4-morpholinyl)-ethanone
CAS Number
2854-32-2
Synonyms
  • BML-190
  • Indomethacin Morpholinylamide
  • LM-4131
Molecular Formula
C23H23ClN2O4
Formula Weight
426.9
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mlDMSO: 12.75 mg/mlEthanol: 1.25 mg/mlPBS acidic: 50 µg/mlPBS basic: 50 µg/mlPBS pH 7.2: 50 µg/ml
SMILES
CC1=C(C(C=C(OC)C=C2)=C2N1C(C3=CC=C(Cl)C=C3)=O)CC(N4CCOCC4)=O
InChi Code
InChI=1S/C23H23ClN2O4/c1-15-19(14-22(27)25-9-11-30-12-10-25)20-13-18(29-2)7-8-21(20)26(15)23(28)16-3-5-17(24)6-4-16/h3-8,13H,9-12,14H2,1-2H3
InChi Key
BJSDNVVWJYDOLK-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

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    10 mg

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    50 mg

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    100 mg

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    Product Description

    IMMA is a cannabinoid (CB) receptor 2 inverse agonist (Ki = 435 nM for recombinant human CB2).1,2 It is selective for CB2 over CB1 receptors (Ki = >20 µM). IMMA (0.001-1 µM) reduces basal production of inositol phosphate and increases forskolin-induced accumulation of cAMP in HEK293 cells expressing human CB2 receptors.2 It inhibits LPS-induced nitric oxide (NO) and prostaglandin E2 (PGE2: Item No. 14010) production in J774 macrophages in a concentration-dependent manner.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

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