A CysLT1 receptor antagonist
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Alternative(s)
10029MK-571
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MK-571 (sodium salt)

Item No. 70720

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(E)-3-[[[3-[2-(7-chloro-2-quinolinyl)ethenyl]phenyl][[3-(dimethylamino)-3-oxopropyl]thio]methyl]thio]-propanoic acid, sodium salt
CAS Number
115103-85-0
Synonyms
  • L-660,711
Molecular Formula
C26H26ClN2O3S2 • Na
Formula Weight
537.1
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 10 mg/mlEthanol: 1 mg/mlH20: 20 mg/mlPBS (pH 7.2): 10 mg/ml
λmax
226, 283, 328, 345, 358 nm
SMILES
ClC1=CC(N=C(/C=C/C2=CC(C(SCCC(N(C)C)=O)SCCC([O-])=O)=CC=C2)C=C3)=C3C=C1.[Na+]
InChi Code
InChI=1S/C26H27ClN2O3S2.Na/c1-29(2)24(30)12-14-33-26(34-15-13-25(31)32)20-5-3-4-18(16-20)6-10-22-11-8-19-7-9-21(27)17-23(19)28-22;/h3-11,16-17,26H,12-15H2,1-2H3,(H,31,32);/q;+1/p-1/b10-6+;
InChi Key
XNAYQOBPAXEYLI-AAGWESIMSA-M
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $36

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    5 mg

    $70

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    10 mg

    $120

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    50 mg

    $502

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    Product Description

    MK-571 is a cysteinyl leukotriene 1 (CysLT1) receptor antagonist (Ki = 2.1 nM in a radioligand binding assay using isolated human lung membranes).1 It inhibits contractions induced by leukotriene D4 (LTD4; Item No. 20310) or LTE4 (Item No. 20410) in histamine-primed isolated guinea pig trachea (pA2s = 9.4 and 9.1, respectively), but does not inhibit contractions induced by LTC4 (Item No. 20210) in histamine-primed isolated guinea pig trachea when used at a concentration of 190 nM. MK-571 (100 nM) inhibits LTD4-induced calcium mobilization in COS-7 monkey kidney cells expressing the human CysLT1 receptor in a reporter assay.2 MK-571 (5 mg/kg) improves tissue damping and elasticity, markers of lung function, and decreases IL-4 and IL-5 levels in bronchoalveolar lavage fluid (BALF) in a mouse model of ovalbumin-induced asthma.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Jones, T.R., Zamboni, R., Belley, M., et al. Pharmacology of L-660,711 (MK-571): A novel potent and selective leukotriene D4 receptor antagonist. Can. J. Physiol. Pharmacol. 67(1), 17-28 (1989).

    2. Lynch, K.R., O'Neill, G.P., Liu, Q., et al. Characterization of the human cysteinyl leukotriene CysLT1 receptor. Nature 399(6738), 789-793 (1999).

    3. da Cunha, A.A., Silveira, J.S., Antunes, G.L., et al. Cysteinyl leukotriene induces eosinophil extracellular trap formation via cysteinyl leukotriene 1 receptor in a murine model of asthma. Exp. Lung Res. 47(8), 355-367 (2021).