A CB2 receptor antagonist
Related Products
Labeled Version(s)
37830SR 144528-d3
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

SR 144528

Item No. 9000491

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-(4-chloro-3-methylphenyl)-1-[(4-methylphenyl)methyl]-N-[(1S,2S,4R)-1,3,3-trimethylbicyclo[2.2.1]hept-2-yl]-1H-pyrazole-3-carboxamide
CAS Number
192703-06-3
Molecular Formula
C29H34ClN3O
Formula Weight
476.1
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 20 mg/mlEthanol: 30 mg/mlEthanol:PBS(pH 7.2) (1:1): 0.5 mg/ml
SMILES
C[C@]1(C2)[C@H](NC(C3=NN(CC4=CC=C(C)C=C4)C(C5=CC(C)=C(Cl)C=C5)=C3)=O)C(C)(C)[C@@H]2CC1
InChi Code
InChI=1S/C29H34ClN3O/c1-18-6-8-20(9-7-18)17-33-25(21-10-11-23(30)19(2)14-21)15-24(32-33)26(34)31-27-28(3,4)22-12-13-29(27,5)16-22/h6-11,14-15,22,27H,12-13,16-17H2,1-5H3,(H,31,34)/t22-,27-,29+/m1/s1
InChi Key
SUGVYNSRNKFXQM-XRHWURSXSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    5 mg

    $129

    Add

    10 mg

    $245

    Add

    25 mg

    $574

    Add

    50 mg

    $1,016

    Add
    Cannabinoid Resource Center
    Discover Our Tools to Support Cannabinoid Research and Analysis.
    • Cannabinoid signaling research products
    • Analytical standards and certified reference materials
    • Endocannabinoid profiling services
    • Lab wall posters
    • Articles, application notes, and webinars
    LEARN MORE
    Product Description

    SR 144528 is a cannabinoid 2 (CB2) receptor antagonist (Ki = 0.6 nM).1 It is selective for CB2 over CB1 receptors in CHO cells expressing the human receptors (Ki = 437 nM).2 SR 144528 reverses CP 55,940-induced inhibition of forskolin-induced adenylyl cyclase activity in CHO cells expressing human CB2 receptors (EC50 = 10 nM). SR 144528 (0.01 mg/kg) reduces paw swelling in a mouse model of carrageenan-induced paw edema.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Pertwee, R.G. Pharmacology of cannabinoid receptor ligands. Curr. Med. Chem. 6(8), 635-664 (1999).

    2. Rinaldi-Carmona, M., Barth, F., Millan, J., et al. SR 144528, the first potent and selective antagonist of the CB2 cannabinoid receptor. J. Pharmacol. Exp. Ther. 284(2), 644-650 (1998).

    3. Iwamura, H., Suzuki, H., Ueda, Y., et al. In vitro and in vivo pharmacological characterization of JTE-907, a novel selection ligand for cannabinoid CB2 receptor. J. Pharmacol. Exp. Ther. 296(2), 420-425 (2001).