A methylated derivative of erlotinib
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Product Type

Biochemicals

Research Area

Cell Biology
Cell Signaling
Growth Factor Receptors

4-methyl Erlotinib

Item No. 9001510

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-(3-ethynyl-4-methylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine
CAS Number
1346601-52-2
Molecular Formula
C23H25N3O4
Formula Weight
407.5
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 50 mg/mlDMF:PBS (pH 7.2) (1:9): 0.1 mg/mlDMSO: 25 mg/mlEthanol: 0.25 mg/ml
λmax
226, 248, 336 nm
SMILES
COCCOC(C(OCCOC)=C1)=CC2=C1C(NC3=CC(C#C)=C(C)C=C3)=NC=N2
InChi Code
InChI=1S/C23H25N3O4/c1-5-17-12-18(7-6-16(17)2)26-23-19-13-21(29-10-8-27-3)22(30-11-9-28-4)14-20(19)24-15-25-23/h1,6-7,12-15H,8-11H2,2-4H3,(H,24,25,26)
InChi Key
PENVNSXCNXIPIF-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    4-methyl Erlotinib is a methylated derivative of erlotinib (Item Nos. 10483 | 35517).1,2 It has been used as an internal standard for the quantification of erlotinib and erlotinib metabolites in human plasma.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Lepper, E.R., Swain, S.M., Tan, A.R., et al. Liquid-chromatographic determination of erlotinib (OSI-774), an epidermal growth factor receptor tyrosine kinase inhibitor. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 796(1), 181-188 (2003).

    2. Svedberg, A., Gréen, H., Vikström, A., et al. A validated liquid chromatography tandem mass spectrometry method for quantification of erlotinib, OSI-420 and didesmethyl erlotinib and semi-quantification of erlotinib metabolites in human plasma. J. Pharm. Biomed. Anal. 107, 186-195 (2015).