Capsiate

Capsiate is a non-pungent analog of capsaicin (Item Nos. 92350 | 10010743) that has been found in C. annuum and has diverse biological activities.^1,2,3,4 It inhibits Src in, as well as VEGF-induced proliferation of and tube formation by, human umbilical vein endothelial cells (HUVECs) when used at concentrations ranging from 5 to 25 µM.¹ Capsiate activates transient receptor potential vanilloid 1 (TRPV1) in HEK293 cells expressing the human channel (EC₅₀ = 290 nM) and induces licking and biting behaviors, markers of nociception, in mice.² Topical application of capsiate reduces antigen-induced increases in ear thickness in a mouse model of passive cutaneous anaphylaxis and decreases epidermal thickness and eosinophil and mast cell infiltration in a mouse model of atopic dermatitis.³ Capsiate (10 mg/kg) decreases body weight gain and perirenal fat weight, as well as increases oxygen consumption, fat oxidation, and carbohydrate oxidation, in a mouse model of ad libitum feeding-induced weight gain.⁴

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1. Pyun, B.-J., Choi, S., Lee, Y., et al. Capsiate, a nonpungent capsaicin-like compound, inhibits angiogenesis and vascular permeability via a direct inhibition of Src kinase activity. Cancer Res. 68(1), 227-235 (2008).

2. Iida, Y., Kobata, T.M., Morita, A., et al. TRPV1 activation and induction of nociceptive response by a non-pungent capsaicin-like compound, capsiate. Neuropharmacology 44(7), 958-967 (2003).

3. Lee, J.J., Lee, Y.S., Lee, E.-J., et al. Capsiate inhibits DNFB-induced atopic dermatitis in NC/Nga mice through mast cell and CD4⁺ T-cell inactivation. J. Invest. Dermatol. 135(8), 1977-1985 (2015).

4. Haramizu, S., Kawabata, F., Ohnuki, K., et al. Capsiate, a non-pungent capsaicin analog, reduces body fat without weight rebound like swimming exercise in mice. Biomed. Res. 32(4), 279-284 (2011).