A CPT1 inhibitor and prodrug form of (+)-etomoxir
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(+)-Etomoxir

Item No. 9004470

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(2R)-2-[6-(4-chlorophenoxy)hexyl]-2-oxiranecarboxylic acid, ethyl ester
CAS Number
124083-20-1
Synonyms
  • (R)-(+)-Etomoxir
Molecular Formula
C17H23ClO4
Formula Weight
326.8
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥10 mg/mlEthanol: Sparingly soluble: 1-10 mg/ml
SMILES
ClC1=CC=C(OCCCCCC[C@@]2(C(OCC)=O)OC2)C=C1
InChi Code
InChI=1S/C17H23ClO4/c1-2-20-16(19)17(13-22-17)11-5-3-4-6-12-21-15-9-7-14(18)8-10-15/h7-10H,2-6,11-13H2,1H3/t17-/m1/s1
InChi Key
DZLOHEOHWICNIL-QGZVFWFLSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    (+)-Etomoxir is an inhibitor of carnitine palmitoyltransferase 1 (CPT1) and a prodrug form of (+)-etomoxir (Item No. 11969).1,2 It is an ethyl ester that is cleaved by intracellular esterases to release the active inhibitor of CPT1.2 (+)-Etomoxir decreases palmitate (Item No. 10010279) oxidation and increases glucose oxidation in isolated rat myocytes when used in a concentration-dependent manner. It reduces mitochondrial oxygen consumption rates and increases free fatty acid levels in LoVo colorectal cancer cells when used at a concentration of 40 µM.3 (+)-Etomoxir (25 mg/kg per day for five days) inhibits kidney tubule necrosis and dilation and reduces blood urea nitrogen (BUN) and serum creatinine levels in a mouse model of acute kidney damage induced by ischemia and reperfusion.4

    WARNING This product is not for human or veterinary use.