Pricing updated 2019-07-23. Prices are subject to change without notice.
Oleoyl ethanolamide (OEA) is an analog of the endocannabinoid AEA found in brain tissue and in chocolate.1 It is one of the long chain fatty acid ethanolamides that accumulates rapidly in infarcted tissue,2 but its biosynthesis is reduced in the intestine of rats following food deprivation.3 OEA is an endogenous, potent agonist for PPARα, exhibiting an EC50 value of 120 nM in a transactivation assay.4 Systemic administration of OEA suppresses food intake and reduces weight gain in rats (10 mg/kg intraperitoneally) and PPARα wild-
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1. di Tomaso, E., Beltramo, M., and Piomelli, D. Brain cannabinoids in chocolate Nature 382, 677-678 (1996).
Epps, D.E., Palmer, J.W., Schmid, H.H.O., et al. Inhibition of permeability-
3. de Fonseca, F.R., Navarro, M., Gómez, R., et al. An anorexic lipid mediator regulated by feeding Nature 414, 209-212 (2001).
Fu, J., Gaetani, S., Oveisi, F., et al. Oleylethanolamide regulates feeding and body weight through activation of the nuclear receptor PPAR-