A potent and selective CB1 receptor agonist
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Arachidonoyl Cyclopropylamide

Item No. 91053

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-cyclopropyl-5Z,8Z,11Z,14Z-eicosatetraenamide
CAS Number
229021-64-1
Synonyms
  • ACPA
Molecular Formula
C23H37NO
Formula Weight
343.6
Purity
≥98%
Formulation
A 50 mg/ml solution in ethanol
Solubility(Learn about Variance in Solubility)
DMF: 15 mg/mlDMSO: 10 mg/mlEthanol: 25 mg/mlEthanol:PBS (pH 7.2) (1:1): 1 mg/ml
SMILES
CCCCC/C=C\C/C=C\C/C=C\C/C=C\CCCC(=O)NC1CC1
InChi Code
InChI=1S/C23H37NO/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-23(25)24-22-20-21-22/h6-7,9-10,12-13,15-16,22H,2-5,8,11,14,17-21H2,1H3,(H,24,25)/b7-6-,10-9-,13-12-,16-15-
InChi Key
GLGAUBPACOBAMV-DOFZRALJSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    5 mg

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    10 mg

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    50 mg

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    100 mg

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    Product Description

    Arachidonoyl cyclopropylamide (ACPA) is a potent and selective cannabinoid (CB) receptor 1 agonist with Ki values of 2.2 and 715 nM for CB1 and CB2 receptors, respectively.1 In whole animal experiments, ACPA induces hypothermia in mice with the same efficacy as arachidonoyl ethanolamide (AEA; Item No. 90050), in spite of its higher affinity for the CB1 receptor. These data have been interpreted to indicate that ACEA may be a substrate for fatty acid amide hydrolase (FAAH), and thus only transiently available in whole animal experiments.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Pertwee, R.G. Pharmacology of cannabinoid receptor ligands. Curr. Med. Chem. 6(8), 635-664 (1999).

    2. Hillard, C.J., Manna, S., Greenberg, M.J., et al. Synthesis and characterization of potent and selective agonists of the neuronal cannabinoid receptor (CB1). J. Pharmacol. Exp. Ther. 289(3), 1427-1433 (1999).