A mineralocorticoid
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Isomer(s)
3087321-Deoxycortisol
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18-hydroxy-11-deoxy Corticosterone

Item No. 10007851

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
18,21-dihydroxy-pregn-4-ene-3,20-dione
CAS Number
379-68-0
Synonyms
  • 18-Hydroxydeoxycorticosterone
  • 18-OH-DOC
Molecular Formula
C21H30O4
Formula Weight
346.5
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mlDMSO: 25 mg/mlEthanol: 25 mg/ml
SMILES
O=C(CO)[C@H]1CC[C@@]2([H])[C@]3([H])CCC4=CC(CC[C@]4(C)[C@@]3([H])CC[C@@]21CO)=O
InChi Code
InChI=1S/C21H30O4/c1-20-8-6-14(24)10-13(20)2-3-15-16(20)7-9-21(12-23)17(15)4-5-18(21)19(25)11-22/h10,15-18,22-23H,2-9,11-12H2,1H3/t15-,16+,17+,18-,20+,21-/m1/s1
InChi Key
VPJHREHKRNIYDB-TZGXILGRSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $194

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    OBESITY RESEARCH SOLUTIONS
    Product Description

    18-hydroxy-11-deoxy Corticosterone (18-OH-DOC) is a mineralocorticoid secreted by the zona fasciculata of the adrenal gland.1,2 Its biosynthesis is regulated by adrenocorticotropic hormone (ACTH; Item No. 24257) as well as angiotensin II (Item No. 17150), which increases 18-OH-DOC production in isolated human adrenal glomerulosa cells.1,3 18-OH-DOC can be formed via conversion of 11-deoxy corticosterone (DOC; Item No. 22916) in human SK-MEL188 melanoma cells.4 18-OH-DOC is an intermediate in the metabolism of progesterone (Item No. 15876) and can be converted to aldosterone (Item No. 15273) by the capsular portion of rat adrenal glands.3,4 Continuous infusion of 18-OH-DOC (200 μg/rat per day) increases systolic blood pressure in uninephrectomized saline-drinking rats.2 Plasma levels of 18-OH-DOC are elevated in a db/db mouse model of type 2 diabetes.5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Braley, L.M., and Williams, G.H. The effect of angiotensin II and saralasin on 18-hydroxy-ll-deoxycorticosterone production by isolated human adrenal glomerulosa cells. J. Clin. Endocrinol. Metab. 49(4), 600-603 (1979).

    2. Carroll, J.C., Komanicky, P., and Melby, J.C. The relationship between plasma 18-hydroxy-11-deoxycorticosterone levels and production of hypertension in the rat. J. Steroid Biochem. 14(10), 989-995 (1981).

    3. Müller, J. The conversion of 18-hydroxycorticosterone and 18-hydroxy-11-deoxycorticosterone to aldosterone by rat adrenal tissue: Evidence for an alternative biosynthetic pathway. J. Steroid Biochem. 13(3), 245-251 (1980).

    4. Slominski, A., Gomez-Sanchez, C.E., Foecking, M.F., et al. Metabolism of progesterone to DOC, corticosterone and 18OHDOC in cultured human melanoma cells. FEBS Lett. 455(3), 364-366 (1999).

    5. Giesbertz, P., Padberg, I., Rein, D., et al. Metabolite profiling in plasma and tissues of ob/ob and db/db mice identifies novel markers of obesity and type 2 diabetes. Diabetologia 58(9), 2133-2143 (2015).