An internal standard for the quantification of pravastatin
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Unlabeled Version(s)
10010343Pravastatin (sodium salt)
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Pravastatin-d3 (sodium salt)

Item No. 25464

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(3R,5R)-3,5-dihydroxy-7-((1S,2S,6S,8S,8aR)-6-hydroxy-2-methyl-8-(((S)-2-(methyl-d3)butanoyl)oxy)-1,2,6,7,8,8a-hexahydronaphthalen-1-yl)heptanoate, monosodium salt
CAS Number
1329836-90-9
Molecular Formula
C23H32D3O7 • Na
Formula Weight
449.5
Purity
≥99% deuterated forms (d1-d3)
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Methanol: Slightly solubleWater: Slightly soluble
SMILES
O=C(O[C@H]1C[C@H](O)C=C2[C@@]1([H])[C@@H](CC[C@@H](O)C[C@@H](O)CC([O-])=O)[C@@H](C)C=C2)[C@@H](C([2H])([2H])[2H])CC.[Na+]
InChi Code
InChI=1S/C23H36O7.Na/c1-4-13(2)23(29)30-20-11-17(25)9-15-6-5-14(3)19(22(15)20)8-7-16(24)10-18(26)12-21(27)28;/h5-6,9,13-14,16-20,22,24-26H,4,7-8,10-12H2,1-3H3,(H,27,28);/q;+1/p-1/t13-,14-,16+,17+,18+,19-,20-,22-;/m0./s1/i2D3;
InChi Key
VWBQYTRBTXKKOG-ZJDKIXRVSA-M
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

    $186

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    1 mg

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    Cayman Chemical
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    OBESITY RESEARCH SOLUTIONS
    Product Description

    Pravastatin-d3 is intended for use as an internal standard for the quantification of pravastatin (Item No. 10010343) by GC- or LC-MS. Pravastatin is a potent and competitive HMG-CoA reductase inhibitor (Ki = 2.3 nM for the active, open ring form of the molecule) that is a ring-hydroxylated metabolite of mevastatin (Item No. 10010340).1 In vivo, pravastatin reduces total plasma cholesterol levels by 29% in dogs when administered at a dose of 20 mg/kg per day for five weeks. Formulations containing pravastatin have been used to reduce LDL cholesterol and triglyceride levels and increase HDL cholesterol in the prevention of cardiovascular disease.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Corsini, A., Maggi, F.M., and Catapano, A.L. Pharmacology of competitive inhibitors of HMG-CoA reductase. Pharmacol. Res. 31(1), 9-27 (1995).