An Analytical Reference Material
Features
  • This product is qualified as a Reference Material that has been manufactured and tested to meet ISO/IEC 17025 and ISO 17034 international standards
  • This product is intended to be used as an analytical reference standard
  • Bulk material is available for qualified institutions; please contact our sales department for pricing
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JWH 018

Item No. 10900

Restricted Product (Schedule I)
Product Insert (PDF)GC-MS (PDF)Safety Data Sheet (SDS) (PDF)
Synonyms
Synonyms
  • AM678
Technical Information
Formal Name
1-naphthalenyl(1-pentyl-1H-indol-3-yl)-methanone
CAS Number
209414-07-3
Molecular Formula
C24H23NO
Formula Weight
341.5
Purity
≥98%
Formulation
A neat solid
SMILES
CCCCCn1cc(C(=O)c2cccc3ccccc23)c2ccccc12
InChi Code
InChI=1S/C24H23NO/c1-2-3-8-16-25-17-22(20-13-6-7-15-23(20)25)24(26)21-14-9-11-18-10-4-5-12-19(18)21/h4-7,9-15,17H,2-3,8,16H2,1H3
InChi Key
JDNLPKCAXICMBW-UHFFFAOYSA-N
Regulatory Information
DEA Schedule
I
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    Product Description

    JWH 018 (Item No. 10900) is an analytical reference material categorized as a synthetic cannabinoid.1 It has been found in Spice/K2-type herbal blends and may have neurotoxic properties. JWH 018 is regulated as a Schedule I compound in the United States. This product is intended for research and forensic applications.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Brents, L.K., Reichard, E.E., Zimmerman, S.M., et al. Phase I hydroxylated metabolites of the K2 synthetic cannabinoid JWH-018 retain in vitro and in vivo cannabinoid 1 receptor affinity and activity. PLoS One 6(7), e21917 (2015).

    Product Citations

    Deventer, M.H., Emanuele, M.C., Stang, B.N., et al. Identification and investigation of the intrinsic receptor activation potential and metabolization of the new oxo-pyridyl synthetic cannabinoid receptor agonist CH-FUBBMPDORA. Drug Test. Anal. (2025).

    Grafinger, K.E., Vandeputte, M.M., Cannaert, A., et al. Systematic evaluation of a panel of 30 synthetic cannabinoid receptor agonists structurally related to MMB-4en-PICA, MDMB-4en-PINACA, ADB-4en-PINACA, and MMB-4CN-BUTINACA using a combination of binding and different CB1 receptor activation assays. Part III: The G protein pathway and critical comparison of different assays. Drug Test. Anal. 13(7), 1412-1429 (2021).

    Cannaert, A., Sparkes, E., Pike, E., et al. Synthesis and in vitro cannabinoid receptor 1 activity of recently detected synthetic cannabinoids 4F-MDMB-BICA, 5F-MPP-PICA, MMB-4en-PICA, CUMYL-CBMICA, ADB-BINACA, APP-BINACA, 4F-MDMB-BINACA, MDMB-4en-PINACA, A-CHMINACA, 5F-AB-P7AICA, 5F-MDMB-P7AICA, and 5F-AP7AICA. ACS Chem. Neurosci. 11(24), 4434-4446 (2020).

    Cho, B., Cho, H.S., Kim, J., et al. Simultaneous determination of synthetic cannabinoids and their metabolites in human hair using LC-MS/MS and application to human hair. Forensic Sci. Int. 306, 110058 (2020).

    Lee, H.Z.S., Koh, H.B., Tan, S., et al. Identification of closely related new psychoactive substances (NPS) using solid deposition gas-chromatography infra-red detection (GC-IRD) spectroscopy. Forensic Sci. Int. 299, 21-33 (2019).

    Ciolino, L.A. Quantitation of synthetic cannabinoids in plant materials using high performance liquid chromatography with UV detection (validated method). J. Forensic Sci. 60(5), 1171-1181 (2015).

    Chimalakonda, K.C., Bratton, S.M., Le, V.-H., et al. Conjugation of synthetic cannabinoids JWH-018 and JWH-073, metabolites by human UDP-glucuronosyltransferases. Drug Metab. Dispos. 39(10), 1967-1976 (2011).