Selective inhibitor of mTOR
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Torin 1

Item No. 10997

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-[4-[4-(1-oxopropyl)-1-piperazinyl]-3-(trifluoromethyl)phenyl]-9-(3-quinolinyl)-benzo[h]-1,6-naphthyridin-2(1H)-one
CAS Number
1222998-36-8
Molecular Formula
C35H28F3N5O2
Formula Weight
607.6
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
λmax
204, 256, 286 nm
SMILES
CCC(N1CCN(C2=CC=C(N3C(C(C=C(C4=CN=C(C=CC=C5)C5=C4)C=C6)=C6N=C7)=C7C=CC3=O)C=C2C(F)(F)F)CC1)=O
InChi Code
InChI=1S/C35H28F3N5O2/c1-2-32(44)42-15-13-41(14-16-42)31-11-9-26(19-28(31)35(36,37)38)43-33(45)12-8-24-20-40-30-10-7-22(18-27(30)34(24)43)25-17-23-5-3-4-6-29(23)39-21-25/h3-12,17-21H,2,13-16H2,1H3
InChi Key
AKCRNFFTGXBONI-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    10 mg

    $161

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    Product Description

    Torin 1 is a potent and selective inhibitor of mTOR (IC50 = 2 and 10 nM for mTORC1 and mTORC2, respectively).1,2 It shows over 100-fold selectivity for mTOR over PI3Kα and other PI3K-like kinases, including ATM, DNA-PK, and hVps34, as well as 450 other protein kinases.1,2 Torin 1, is efficacious at a dose of 20 mg/kg in inhibiting downstream effectors of mTOR in mice.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Thoreen, C.C., Kang, S.A., Chang, J.W., et al. An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1. The Journal of Biological Chemisty 284(12), 8023-8032 (2009).

    2. Liu, Q., Chang, W., Wang, J., et al. Discovery of 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo[h][1,6]naphthyridin-2(1H)-one as a highly potent, selective mammalian target of rapamycin (mTOR) inhibitor for the treatment of cancer. J. Med. Chem. 53(19), 7146-7155 (2010).

    Product Citations

    Armenta, D.A., Laqtom, N.N., Alchemy, G., et al. Ferroptosis inhibition by lysosome-dependent catabolism of extracellular protein. Cell Chem. Biol. 29(11), 1588-1600 (2022).

    Yi, J., Zhu, J., Wu, J., et al. Oncogenic activation of PI3K-AKT-mTOR signaling suppresses ferroptosis via SREBP-mediated lipogenesis. Proc. Natl. Acad. Sci. USA 202017152 (2020).