An active metabolite of aflatoxin B1
Related Products
Isomer(s)
11295Aflatoxin G1
Labeled Version(s)
31264Aflatoxin M1-13C17
Parent Compound(s)
11293Aflatoxin B1
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Aflatoxin M1

Item No. 11297

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(6aR,9aR)-2,3,6a,9a-tetrahydro-9a-hydroxy-4-methoxy-cyclopenta[c]furo[3',2':4,5]furo[2,3-h][1]benzopyran-1,11-dione
CAS Number
6795-23-9
Synonyms
  • AFM1
Molecular Formula
C17H12O7
Formula Weight
328.3
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile:Methanol (1:1): 1 mg/ml
SMILES
O=C1C2=C(CCC2=O)C3=C(C([C@@](C=CO4)(O)[C@@]4([H])O5)=C5C=C3OC)O1
InChi Code
InChI=1S/C17H12O7/c1-21-9-6-10-13(17(20)4-5-22-16(17)23-10)14-12(9)7-2-3-8(18)11(7)15(19)24-14/h4-6,16,20H,2-3H2,1H3/t16-,17-/m1/s1
InChi Key
MJBWDEQAUQTVKK-IAGOWNOFSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    100 µg

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    Product Description

    Aflatoxin M1 (AFM1) is an active metabolite of aflatoxin B1 (Item No. 11293).1 It induces hepatocyte hyperplasia and hepatocellular carcinoma tumor formation in rats when administered at a dose of 1 mg/animal. AFM1 (6 mg/kg) increases hepatic total lipid levels and inhibits hepatic mitochondrial and cytoplasmic protein synthesis in rats.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Wogan, G.N., and Paglialunga, S. Carcinogenicity of synthetic aflatoxin M1 in rats. Food Cosmet. Toxicol. 12(3), 381-385 (1974).

    2. Pai, M.R., Bai, N.J., and Venkitasubramanian, T.A. Aflatoxin induced inhibition of protein synthesis. Toxicon 16(3), 283-287 (1978).