A selective CB1 receptor antagonist
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LY320135

Item No. 11738

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[[6-methoxy-2-(4-methoxyphenyl)-3-benzofuranyl]carbonyl]-benzonitrile
CAS Number
176977-56-3
Molecular Formula
C24H17NO4
Formula Weight
383.4
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mlDMSO: 25 mg/mlDMSO:PBS(pH7.2) (1:1): 0.5 mg/mlEthanol: 0.2 mg/ml
λmax
247, 302, 364 nm
SMILES
O=C(C1=C(C2=CC=C(OC)C=C2)OC3=C1C=CC(OC)=C3)C4=CC=C(C#N)C=C4
InChi Code
InChI=1S/C24H17NO4/c1-27-18-9-7-17(8-10-18)24-22(20-12-11-19(28-2)13-21(20)29-24)23(26)16-5-3-15(14-25)4-6-16/h3-13H,1-2H3
InChi Key
RYNSGDFWBJWWSZ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $32

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    5 mg

    $110

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    10 mg

    $205

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    Product Description

    LY320135 is a selective cannabinoid (CB) receptor 1 antagonist (Kis = 224 and >10,000 nM for CB1 and CB2, respectively, in vitro).1 It is selective for CB1 over α1- and α2- adrenergic, D1 and D2 dopamine, benzodiazepine, histamine H1, GABA, serotonin (5-HT), and muscarinic receptors. It reverses the inhibition of forskolin-induced cAMP accumulation induced by arachidonoyl ethanolamide (anandamide; Item No. 90050) in CHO cells and inhibits a stimulatory effect of arachidonoyl ethanolamide on adenylate cyclase induced by application of pertussis toxin (IC50 = 734 nM). LY320135 (1 mg/kg) reverses inhibition of light-induced phase shifts in hamsters induced by the CB1 agonist CP 55,940 (Item No. 90084).2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Felder, C.C., Joyce, K.E., Briley, E.M., et al. LY320135, a novel cannabinoid CB1 receptor antagonist, unmasks coupling of the CB1 receptor to stimulation of cAMP accumulation. J. Pharmacol. Exp. Ther. 284(1), 291-297 (1998).

    2. Sanford, A.E., Castillo, E., and Gannon, R.L. Cannabinoids and hamster circadian activity rhythms. Brain Res. 1222, 141-148 (2008).