A natural non-caloric sweetener
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Isomer(s)
33199Rebaudioside B
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Stevioside (hydrate)

Item No. 11902

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
13-[(2-O-β-D-glucopyranosyl-β-D-glucopyranosyl)oxy]-kaur-16-en-18-oic acid, (4α)-β-D-glucopyranosyl ester, hydrate
Synonyms
  • 19-O-β-Glucopyranosyl-13-O-β-glucopyranosyl-(1-2)-β-glucopyranosyl-steviol
Molecular Formula
C38H60O18 • XH2O
Formula Weight
804.9
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlDMSO:PBS (pH 7.2) (1:8): 0.11 mg/ml
SMILES
C[C@]([C@]1([H])CC2)(CCC[C@@]1(C)C(O[C@@H]([C@@H]([C@@H](O)[C@@H]3O)O)O[C@@H]3CO)=O)[C@@]4([H])[C@]2(CC5=C)C[C@@]5(O[C@@](O[C@H](CO)[C@@H](O)[C@@H]6O)([H])[C@@H]6O[C@]([C@@H]([C@@H](O)[C@@H]7O)O)([H])O[C@@H]7CO)CC4.O
InChi Code
InChI=1S/C38H60O18.H2O/c1-16-11-37-9-5-20-35(2,7-4-8-36(20,3)34(50)55-32-29(49)26(46)23(43)18(13-40)52-32)21(37)6-10-38(16,15-37)56-33-30(27(47)24(44)19(14-41)53-33)54-31-28(48)25(45)22(42)17(12-39)51-31;/h17-33,39-49H,1,4-15H2,2-3H3;1H2/t17-,18-,19-,20+,21+,22-,23-,24-,25+,26+,27+,28-,29-,30-,31+,32+,33+,35-,36-,37-,38+;/m1./s1
InChi Key
FVECWZKNZGXJJO-QMYNVHDOSA-N
Origin
Plant/Stevia rebaudiana
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $53

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    10 mg

    $94

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    50 mg

    $332

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    Cayman Chemical
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    OBESITY RESEARCH SOLUTIONS
    Product Description

    Stevioside is a natural non-caloric sweetener and glycoside form of steviol (Item No. 10011344) that has been found in S. rebaudiana and has diverse biological activities.1,2,3,4,5 It increases glucose-stimulated insulin secretion in isolated mouse pancreatic islets when used at a concentration of 1 µM.2 Stevioside (1 mM) reduces LPS-stimulated increases in TNF-α and IL-1β production in THP-1 cells, but also induces TNF-α and IL-1β production in unstimulated THP-1 cells.3 It decreases systolic blood pressure in Goto-Kakizaki (GK) type 2 diabetic rats when administered at a dose of 0.03 g/kg.4 Stevioside reduces ear edema induced by 12-O-tetradecanoylphorbol-13-acetate (TPA; Item No. 10008014) in mice (ID50 = 291.6 µg/ear).5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Sclafani, A., Bahrani, M., Zukerman, S., et al. Stevia and saccharin preferences in rats and mice. Chem. Senses 35(5), 433-443 (2010).

    2. Chen, J., Jeppesen, P.B., Nordentoft, I., et al. Stevioside improves pancreatic β-cell function during glucotoxicity via regulation of acetyl-CoA carboxylase. Am. J. Physiol. Endocrinol. Metab. 292(6), E1906-E1916 (2007).

    3. Boonkaewwan, C., Toskulkao, C., and Vongsakul, M. Anti-inflammatory and immunomodulatory activities of stevioside and Its metabolite steviol on THP-1 cells. J. Agric. Food Chem. 54(3), 785-789 (2006).

    4. Jeppesen, P.B., Dyrskog, S.E., Agger, A., et al. Can stevioside in combination with a soy-based dietary supplement be a new useful treatment in type 2 diabetes? An in vivo study in the diabetic goto-kakizaki rat. Rev. Diabet. Stud. 3(4), 189-199 (2006).

    5. Yasukawa, K., Kitanaka, S., and Seo, S. Inhibitory effect of stevioside on tumor promotion by 12-O-tetradecanoylphorbol-13-acetate in two-stage carcinogenesis in mouse skin. Biol. Pharm. Bull. 25(11), 1488-1490 (2002).

    Product Citations

    Ribeiro, M.M., Diamantino, T., Domingues, J., et al. Stevia rebaudiana germplasm characterization using microsatellite markers and steviol glycosides quantification by HPLC. Mol. Biol. Rep. 48(3), 2573-2582 (2021).