An AT1 receptor antagonist
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Labeled Version(s)
25509Irbesartan-d4
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Irbesartan

Item No. 11952

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-butyl-3-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1,3-diazaspiro[4.4]non-1-en-4-one
CAS Number
138402-11-6
Synonyms
  • BMS 186295
  • SR 47436
Molecular Formula
C25H28N6O
Formula Weight
428.5
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 14 mg/mlEthanol: 0.5 mg/ml
SMILES
CCCCC1=NC2(CCCC2)C(N1CC3=CC=C(C4=C(C5=NNN=N5)C=CC=C4)C=C3)=O
InChi Code
InChI=1S/C25H28N6O/c1-2-3-10-22-26-25(15-6-7-16-25)24(32)31(22)17-18-11-13-19(14-12-18)20-8-4-5-9-21(20)23-27-29-30-28-23/h4-5,8-9,11-14H,2-3,6-7,10,15-17H2,1H3,(H,27,28,29,30)
InChi Key
YOSHYTLCDANDAN-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    10 mg

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    Cayman Chemical
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    OBESITY RESEARCH SOLUTIONS
    Product Description

    Irbesartan is an antagonist of the angiotensin II type 1 (AT1) receptor (Ki = 1.3 nM).1 It is an insurmountable antagonist of AT1, as its antagonism cannot be overcome by increasing concentrations of angiotensin II.2 Irbesartan (3, 10, and 30 mg/kg) reduces blood pressure in stroke-prone spontaneously hypertensive rats and increases survival of SPSH rats fed a high-salt low-protein diet.3 It also reduces plaque formation, collagen content, as well as the increased expression of the AT1 receptor, PDGF-b, MCP-1, and VCAM-1 in a model of diabetes-induced atherosclerosis using apolipoprotein E (ApoE) knockout mice with diabetes induced by streptozotocin (STZ; Item No. 13104).4 Formulations containing irbesartan have been used, alone and in combination with diuretics, in the treatment of hypertension.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Burnier, M. Angiotensin II type 1 receptor blockers. Circulation 103(6), 904-912 (2001).

    2. Gradman, A.H. AT1-receptor blockers: Differences that matter. J. Hum. Hypertens. 16, S9-S16 (2002).

    3. Shimamura, T., Masui, M., Torii, M., et al. Hypotensive and prophylactic effects of angiotensin II subtype 1 receptor antagonist, irbesartan, in stroke-prone spontaneously hypertensive rats. Clin. Exp. Hypertens. 26(1), 27-42 (2004).

    4. Candido, R., Allen, T.J., Lassila, M., et al. Irbesartan but not amlodipine suppresses diabetes-associated atherosclerosis. Circulation 109(12), 1536-1542 (2004).