An antiallergic agent
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Tranilast

Item No. 13044

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[[3-(3,4-dimethoxyphenyl)-1-oxo-2-propen-1-yl]amino]-benzoic acid
CAS Number
53902-12-8
Synonyms
  • 3,4-DAA
  • N-(3',4'-Dimethyoxycinnamoyl) Anthranilic Acid
  • N-5'
  • MK 341
  • SB 252218
Molecular Formula
C18H17NO5
Formula Weight
327.3
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 35 mg/mlDMSO: 20 mg/mlEthanol: 2 mg/mlPBS (pH 7.2): 0.2 mg/ml
λmax
339 nm
SMILES
O=C(/C=C/C1=CC=C(OC)C(OC)=C1)NC2=C(C(O)=O)C=CC=C2
InChi Code
InChI=1S/C18H17NO5/c1-23-15-9-7-12(11-16(15)24-2)8-10-17(20)19-14-6-4-3-5-13(14)18(21)22/h3-11H,1-2H3,(H,19,20)(H,21,22)/b10-8+
InChi Key
NZHGWWWHIYHZNX-CSKARUKUSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

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    50 mg

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    Product Description

    Tranilast is an antiallergic agent.1 It inhibits prostaglandin E2 (PGE2; Item No. 14010) and PGD2 (Item No. 12010) production induced by A23187 (Item Nos. 11016 | 22030) in isolated rat peritoneal mast cells when used at a concentration of 100 µM, as well as LPS-stimulated production of PGE2 and thromboxane B2 (TXB2; Item No. 19030) in isolated human monocytes (IC50s = ~3 and ~35 µM, respectively).2,3 Tranilast (500 µM) reduces mast cell degranulation induced by compound 48/80 (Item No. 22173).1 It inhibits VEGF-stimulated proliferation, migration, and tube formation of bovine retinal endothelial cells (IC50s = 22, 18, and 193 µM, respectively).4 Tranilast (200 mg/kg) prevents homologous passive cutaneous anaphylaxis (PCA) in guinea pigs.5 Formulations containing tranilast have been used in the treatment of asthma and keloid and hypertrophic scars.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Baba, A., Tachi, M., Ejima, Y., et al. Anti-allergic drugs tranilast and ketotifen dose-dependently exert mast cell-stabilizing properties. Cell Physiol. Biochem. 38(1), 15-27 (2016).

    2. Ikai, K., Ujihara, M., Fujii, K., et al. Inhibitory effect of tranilast on prostaglandin D synthetase. Biochem. Pharmacol. 38(16), 2673-2676 (1989).

    3. Capper, E.A., Roshak, A.K., Bolognese, B.J., et al. Modulation of human monocyte activities by tranilast, SB 252218, a compund demonstrating efficacy in restenosis. J. Pharmacol. Exp. Ther. 295(3), 1061-1069 (2000).

    4. Koyama, S., Takagi, H., Otani, A., et al. Tranilast inhibits protein kinase C-dependent signalling pathway linked to angiogenic activities and gene expression of retinal microcapillary endothelial cells. Br. J. Pharmacol. 127(2), 537-545 (1999).

    5. Koda, A., Nagai, H., Watanabe, S., et al. Inhibition of hypersensitivity reactions by a new drug, N(3’,4’-dimethoxycinnamoyl) anthranilic acid (N-5’). J. Allergy Clin. Immunol. 57(5), 396-407 (1975).