An inhibitor of the oxidized and reduced forms of xanthine oxidase
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Labeled Version(s)
25033Febuxostat-d9
Metabolite(s)
26599Febuxostat Acyl Glucuronide
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Febuxostat

Item No. 14127

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[3-cyano-4-(2-methylpropoxy)phenyl]-4-methyl-5-thiazolecarboxylic acid
CAS Number
144060-53-7
Synonyms
  • FBX
  • TEI 6720
  • TMX 67
Molecular Formula
C16H16N2O3S
Formula Weight
316.4
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMF:PBS (pH 7.2) (1:1): 0.5 mg/mlDMSO: 10 mg/mlEthanol: 5 mg/ml
λmax
217, 317 nm
SMILES
CC(C)COC1=C(C#N)C=C(C2=NC(C)=C(C(O)=O)S2)C=C1
InChi Code
InChI=1S/C16H16N2O3S/c1-9(2)8-21-13-5-4-11(6-12(13)7-17)15-18-10(3)14(22-15)16(19)20/h4-6,9H,8H2,1-3H3,(H,19,20)
InChi Key
BQSJTQLCZDPROO-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $63

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    10 mg

    $118

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    25 mg

    $274

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    50 mg

    $481

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    Cayman Chemical
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    Product Description

    Febuxostat is an antihyperuricemic nonpurine inhibitor of both the oxidized and reduced forms of xanthine oxidase.1 It inhibits bovine milk xanthine oxidase as well as mouse and rat liver xanthine oxidase/xanthine dehydrogenase (IC50s = 1.4, 1.8, and 2.2 nM, respectively).2 It is 10-30 times more potent than the hypoxanthine analog allopurinol (Item No. 10012597; Kis = 0.7 nM and 0.7 μM, respectively).3,4 Febuxostat decreases the serum level of urate in a potassium oxonate rat model of hyperuricemia (ED50 = 1.5 mg/kg).2 It reduces hepatic macrovesicular steatosis in mice fed a high-fat diet containing trans fatty acids when administered at a dose of 1 mg/kg per day.5 Febuxostat (0.75 mg/kg) also increases CNS expression of glutamate oxaloacetate transaminase 2 (GOT2) and improves neurological symptoms in a mouse model of secondary progressive experimental autoimmune encephalomyelitis (EAE).6 Formulations containing febuxostat have been used in the treatment of symptomatic hyperuricemia in patients with gout.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

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