(-)-Cotinine (CAS 486-56-6) | Cayman Chemical
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(−)-Cotinine

Item № 15314
CAS № 486-56-6
Purity ≥98%
product image
                (CAS 486-56-6)
SIZE PRICE QUANTITY SUBTOTAL
CART TOTAL
     50 mg $45.00 0.00
     100 mg $59.00 0.00
     250 mg $74.00 0.00
     500 mg $135.00 0.00

Pricing updated 2019-01-16. Prices are subject to change without notice.

Description
Synonyms
  • NIH 10498

Cotinine is a minor alkaloid found in tobacco plants and is a major metabolite of nicotine.1 It has a long pharmacological half-life (15-19 hours) compared to that of nicotine (2-3 hours) and is often used as a biomarker to detect tobacco use.2,3,4 Cotinine binds nicotinic- and muscarinic-type acetylcholine receptors with minimal receptor desensitization and demonstrates antipsychotic drug-like properties in behavioral models, neuroprotective properties in neurodegenerative disease models, and enhances attention in a delayed matching-to-sample task.2

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Technical Information
Formal Name
1-methyl-5S-(3-pyridinyl)-2-pyrrolidinone
CAS Number
486-56-6
Synonyms
  • NIH 10498
Molecular Formula
C10H12N2O
Formula Weight
176.2
Purity
≥98%
Formulation
A crystalline solid
λmax
262 nm
SMILES
O=C1CC[C@@H](C2=CN=CC=C2)N1C
InChI Code
InChI=1S/C10H12N2O/c1-12-9(4-5-10(12)13)8-3-2-6-11-7-8/h2-3,6-7,9H,4-5H2,1H3/t9-/m0/s1
InChI Key
UIKROCXWUNQSPJ-VIFPVBQESA-N

Warning - this product is not for human or veterinary use.

Shipping & Storage
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Stability
≥ 2 years
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Additional Information

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References & Product Citations
Product Description References

1. Clemens, K.J., Caillé, S., Stinus, L., et al. The addition of five minor tobacco alkaloids increases nicotine-induced hyperactivity, sensitization and intravenous self-administration in rats Int.J.Neuropsychopharmacol. 12(10), 1355-1366 (2009).

2. Terry, A.V., Jr., Hernandez, C.M., Hohnadel, E.J., et al. Cotinine, a neuroactive metabolite of nicotine: Potential for treating disorders of impaired cognition CNS Drug Rev. 11(3), 229-252 (2005).

3. Jacob, P., III, Yu, L., Shulgin, A.T., et al. Minor tobacco alkaloids as biomarkers for tobacco use: Comparison of users of cigarettes, smokeless tobacco, cigars, and pipes Am.J.Public Health 89(5), 731-736 (1999).

4. Murphy, S.E., Link, C.A., Jensen, J., et al. A comparison of urinary biomarkers of tobacco and carcinogen exposure in smokers Cancer Epidemiology, Biomarkers & Prevention 13(10), 1617-1623 (2004).

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