An Analytical Reference Material
Features
  • This product is qualified as a Reference Material that has been manufactured and tested to meet ISO/IEC 17025 and ISO 17034 international standards
  • This product is intended to be used as an analytical reference standard
  • Bulk material is available for qualified institutions; please contact our sales department for pricing
Related Products
Active Metabolite(s)
21536Dihydromorphine (hydrate)
Analytical Standard(s)
37884Dihydrocodeine
Certified Reference Material(s)
ISO60142Dihydrocodeine (CRM)
Isomer(s)
215346β-Hydrocodol
Parent Compound(s)
15461Hydrocodone 22166Hydrocodone (bitartrate) ISO60144Hydrocodone (CRM)
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Dihydrocodeine

Item No. 15460

Restricted Product (Schedule II)
Product Insert (PDF)GC-MS (PDF)Safety Data Sheet (SDS) (PDF)
Synonyms
Synonyms
  • DH-Codeine
  • Dihydrin
  • Drocode
  • 6α-Hydrocodol
  • NSC 231319
  • Paracodine
Technical Information
Formal Name
4,5α-epoxy-3-methoxy-17-methyl-morphinan-6α-ol
CAS Number
125-28-0
Molecular Formula
C18H23NO3
Formula Weight
301.4
Purity
≥98%
Formulation
A neat solid
SMILES
O[C@@H](CC[C@@]1([H])[C@H]2CC3=CC=C4OC)[C@@]5([H])[C@]1(CCN2C)C3=C4O5
InChi Code
InChI=1S/C18H23NO3/c1-19-8-7-18-11-4-5-13(20)17(18)22-16-14(21-2)6-3-10(15(16)18)9-12(11)19/h3,6,11-13,17,20H,4-5,7-9H2,1-2H3/t11-,12+,13-,17-,18-/m0/s1
InChi Key
RBOXVHNMENFORY-DNJOTXNNSA-N
Regulatory Information
DEA Schedule
II
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    Product Description

    Dihydrocodeine (Item No. 15460) is an analytical reference material categorized as an opioid.1 Dihydrocodeine is an active metabolite of hydrocodone (Item Nos. ISO60144 | 15461 | 22166).2 Formulations containing dihydrocodeine have been used in the treatment of severe pain and have been associated with misuse and polypharmacy-related overdose.3 Dihydrocodeine is regulated as a Schedule II compound in the United States. This product is intended for research and forensic applications.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Thompson, C.M., Wojno, H., Greiner, E., et al. Activation of G-proteins by morphine and codeine congeners: Insights to the relevance of O- and N-demethylated metabolites at μ- and δ-opioid receptors. J. Pharmacol. Exp. Ther. 308(2), 547-554 (2004).

    2. Cone, E.J., Darwin, W.D., Gorodetzky, C.W., et al. Comparative metabolism of hydrocodone in man, rat, guinea pig, rabbit, and dog. Drug Metab. Dispos. 6(4), 488-493 (1978).

    3. Rock, K.L., Reynolds, L.M., Rees, P., et al. Highlighting the hidden dangers of a “weak” opioid: Deaths following use of dihydrocodeine in England (2001-2020). Drug Alcohol Depend. 233, 109376 (2022).