A prodrug form of N-desethyl amodiaquine
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Amodiaquine

Item No. 15954

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[(7-chloro-4-quinolinyl)amino]-2-[(diethylamino)methyl]-phenol
CAS Number
86-42-0
Synonyms
  • Camoquine
  • Flavoquine
  • NSC 13453
  • SN 10751
Molecular Formula
C20H22ClN3O
Formula Weight
355.9
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 2.5 mg/mlDMSO: 5 mg/mlEthanol: 2 mg/ml
λmax
224, 343 nm
SMILES
OC(C=C1)=C(CN(CC)CC)C=C1NC2=CC=NC3=C2C=CC(Cl)=C3
InChi Code
InChI=1S/C20H22ClN3O/c1-3-24(4-2)13-14-11-16(6-8-20(14)25)23-18-9-10-22-19-12-15(21)5-7-17(18)19/h5-12,25H,3-4,13H2,1-2H3,(H,22,23)
InChi Key
OVCDSSHSILBFBN-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Cayman Chemical
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    Product Description

    Amodiaquine is a prodrug form of the antimalarial compound N-desethyl amodiaquine (Item No. 20822).1,2 It is active against several strains of P. falciparum in vitro (EC50s = 0.23-0.52 nM) and exhibits a synergistic effect when used in combination with N-desethyl amodiaquine.1 Amodiaquine dose-dependently inhibits development of parasitemia in a mouse model of P. berghei infection.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Mariga, S.T., Gil, J.P., Sisowath, C., et al. Synergism between amodiaquine and its major metabolite, desethylamodiaquine, against Plasmodium falciparum in vitro. Antimicrob. Agents Chemother. 48(11), 4089-4096 (2004).

    2. Sá, J.M., Chong, J.L., and Wellems, T.E. Malaria drug resistance: New observations and developments. Essays Biochem. 51, 137-160 (2014).

    3. Jacobs, R.L., Alling, D.W., and Cantrell, W.F. An evaluation of antimalarial combinations against Plasmodium berghei in the mouse. J. Parasitol. 49(6), 920-925 (1963).