A mycotoxin
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Labeled Version(s)
40238Ochratoxin B-13C20
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Environmental Toxicology
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Ochratoxin B

Item No. 16167

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[[(3R)-3,4-dihydro-8-hydroxy-3-methyl-1-oxo-1H-2-benzopyran-7-yl]carbonyl]-L-phenylalanine
CAS Number
4825-86-9
Synonyms
  • OTB
Molecular Formula
C20H19NO6
Formula Weight
369.4
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 15 mg/mlEthanol: 50 mg/mlEthanol:PBS (pH 7.2) (1:1): 0.50 mg/ml
λmax
218, 319 nm
SMILES
O=C1O[C@@H](C)CC2=C1C(O)=C(C(N[C@H](C(O)=O)CC3=CC=CC=C3)=O)C=C2
InChi Code
InChI=1S/C20H19NO6/c1-11-9-13-7-8-14(17(22)16(13)20(26)27-11)18(23)21-15(19(24)25)10-12-5-3-2-4-6-12/h2-8,11,15,22H,9-10H2,1H3,(H,21,23)(H,24,25)/t11-,15-/m0/s1
InChi Key
DAEYIVCTQUFNTM-NHYWBVRUSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    Ochratoxin B (OTB) is a mycotoxin that has been found in Aspergillus and is a non-chlorinated derivative of OTA (Item No. 11439).1 Unlike OTA, OTB is not genotoxic to HepG2 cells but does inhibit cell division when used at concentrations ranging from 1 to 25 µg/ml.2 It induces mortality (LC50 = 700 nM) and craniofacial malformations (EC50 = 200 nM) in Xenopus embryos.3 OTB has been found in poultry feed.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Varga, J., Kevei, E., Rinyu, E., et al. Ochratoxin production by Aspergillus species. Appl. Environ. Microbiol. 62(12), 4461-4464 (1996).

    2. Knasmüller, S., Cavin, C., Chakraborty, A., et al. Structurally related mycotoxins ochratoxin A, ochratoxin B, and citrinin differ in their genotoxic activities and in their mode of action in human-derived liver (HepG2) cells: Implications for risk assessment. Nutr. Cancer 50(2), 190-197 (2004).

    3. O'Brien, E., Prietz, A., and Dietrich, D.R. Investigation of the teratogenic potential of ochratoxin A and B using the FETAX system. Birth Defects Res. B Dev. Reprod. Toxicol. 74(5), 417-423 (2005).

    4. Ezekiel, C.N., Bandyopadhyay, R., Sulyok, M., et al. Fungal and bacterial metabolites in commercial poultry feed from Nigeria. Food Addit. Contam. Part A Chem. Anal. Control Expo. Risk Assess. 29(8), 1288-1299 (2012).