An internal standard for the quantification of ochratoxin B
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Unlabeled Version(s)
16167Ochratoxin B
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Ochratoxin B-13C20

Item No. 40238

Technical Information
Formal Name
((R)-8-hydroxy-3-(methyl-13C)-1-oxoisochromane-7-carbonyl-13C9)-L-phenylalanine-13C9
Synonyms
  • OTB-13C20
Molecular Formula
[13C]20H19NO6
Formula Weight
Purity
≥98%
Formulation
A 10 µg/ml solution in methanol
SMILES
O[13C]([13C@H]([13CH2][13C]1=[13CH][13CH]=[13CH][13CH]=[13CH]1)N[13C]([13C]2=[13CH][13CH]=[13C]([13CH2][13C@@H]([13CH3])O[13C]3=O)[13C]3=[13C]2O)=O)=O
InChi Code
InChI=1S/C20H19NO6/c1-11-9-13-7-8-14(17(22)16(13)20(26)27-11)18(23)21-15(19(24)25)10-12-5-3-2-4-6-12/h2-8,11,15,22H,9-10H2,1H3,(H,21,23)(H,24,25)/t11-,15+/m1/s1/i1+1,2+1,3+1,4+1,5+1,6+1,7+1,8+1,9+1,10+1,11+1,12+1,13+1,14+1,15+1,16+1,17+1,18+1,19+1,20+1
InChi Key
DAEYIVCTQUFNTM-IUPBDDTRSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    Product Description

    Ochratoxin B-13C20 (OTB-13C20) is intended for use as an internal standard for the quantification of ochratoxin B (Item No. 16167) by GC- or LC-MS. OTB is a mycotoxin that has been found in Aspergillus and is a non-chlorinated derivative of OTA (Item No. 11439).1 Unlike OTA, OTB is not genotoxic to HepG2 cells but does inhibit cell division when used at concentrations ranging from 1 to 25 µg/ml.2 It induces mortality (LC50 = 700 nM) and craniofacial malformations (EC50 = 200 nM) in Xenopus embryos.3 OTB has been found in poultry feed.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Varga, J., Kevei, E., Rinyu, E., et alOchratoxin production by Aspergillus species. Appl. Environ. Microbiol. 62(12), 4461-4464 (1996).

    2. Knasmüller, S., Cavin, C., Chakraborty, A., et alStructurally related mycotoxins ochratoxin A, ochratoxin B, and citrinin differ in their genotoxic activities and in their mode of action in human-derived liver (HepG2) cells: Implications for risk assessment. Nutr. Cancer 50(2), 190-197 (2004).

    3. O'Brien, E., Prietz, A., and Dietrich, D.R. Investigation of the teratogenic potential of ochratoxin A and B using the FETAX system. Birth Defects Res. B Dev. Reprod. Toxicol. 74(5), 417-423 (2005).

    4. Ezekiel, C.N., Bandyopadhyay, R., Sulyok, M., et alFungal and bacterial metabolites in commercial poultry feed from Nigeria. Food Addit. Contam. Part A Chem. Anal. Control Expo. Risk Assess. 29(8), 1288-1299 (2012).