An inhibitor of BRD4, TAF1, and TAF1L bromodomains
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UMB-32

Item No. 17123

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-(1,1-dimethylethyl)-2-[4-(3,5-dimethyl-4-isoxazolyl)phenyl]-imidazo[1,2-a]pyrazin-3-amine
CAS Number
1635437-39-6
Molecular Formula
C21H23N5O
Formula Weight
361.4
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 10 mg/mlEthanol: 20 mg/mlEthanol:PBS (pH 7.2) (1:5): 0.1 mg/ml
λmax
258, 345 nm
SMILES
CC(C)(C)NC1=C(N=C2N1C=CN=C2)C3=CC=C(C4=C(C)ON=C4C)C=C3
InChi Code
InChI=1S/C21H23N5O/c1-13-18(14(2)27-25-13)15-6-8-16(9-7-15)19-20(24-21(3,4)5)26-11-10-22-12-17(26)23-19/h6-12,24H,1-5H3
InChi Key
YXPVTKHEWGXKEY-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $54

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    5 mg

    $238

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    10 mg

    $418

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    25 mg

    $913

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    Product Description

    UMB-32 is an inhibitor of the BET bromodomain BRD4 (Kd = 550 nM; IC50 = 637 nM) and the bromodomain-containing transcription factor TAF1 (Kd = 560 nM) and TAF1L (Kd = 1.3 µM).1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. McKeown, M.R., Shaw, D.L., Fu, H., et al. Biased multicomponent reactions to develop novel bromodomain inhibitors. J. Med. Chem. 57(21), 9019-9027 (2014).