A prodrug form of 10,11-dihydro-10-hydroxy carbamazepine
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Oxcarbazepine

Item No. 17340

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
10,11-dihydro-10-oxo-5H-dibenz[b,f]azepine-5-carboxamide
CAS Number
28721-07-5
Synonyms
  • GP47680
Molecular Formula
C15H12N2O2
Formula Weight
252.3
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMF:PBS (pH 7.2) (1:1): 0.5 mg/mlDMSO: 10 mg/ml
λmax
256, 308 nm
SMILES
O=C1C2=C(C=CC=C2)N(C(N)=O)C3=C(C=CC=C3)C1
InChi Code
InChI=1S/C15H12N2O2/c16-15(19)17-12-7-3-1-5-10(12)9-14(18)11-6-2-4-8-13(11)17/h1-8H,9H2,(H2,16,19)
InChi Key
CTRLABGOLIVAIY-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    10 mg

    $36

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    50 mg

    $153

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    100 mg

    $236

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    250 mg

    $294

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    Product Description

    Oxcarbazepine is a prodrug form of the antiepileptic compound 10,11-dihydro-10-hydroxy carbamazepine (Item No. 18467).1,2 It inhibits high-frequency repetitive firing of rat spinal cord neurons when used at a concentration of 1 µM.2 Oxcarbazepine protects against electroshock-induced tonic hindlimb extension (ED50 = 10-20 mg/kg), as well as seizures induced by pentylenetetrazole (PTZ; Item No. 18682) or picrotoxin (Item No. 20771) in rodents (ED50s = 23-30 and 150-250 mg/kg, respectively). Formulations containing oxcarbazepine have been used in the treatment of epileptic seizures.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ambrósio, A.F., Soares-Da-Silva, P., Carvalho, C.M., et al. Mechanisms of action of carbamazepine and its derivatives, oxcarbazepine, BIA 2-093, and BIA 2-024. Neurochem. Res. 27(1-2), 121-130 (2002).

    2. McLean, M.J., Schmutz, M., Wamil, A.W., et al. Oxcarbazepine: Mechanisms of action. Epilepsia 35(Suppl. 3), S5-S9 (1994).